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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C


Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLC beta 2 axis

DC Field Value Language Maeng, Yong-Sun ko Choi, Hyun-Jung ko Kwon, Ja-Young ko Park, Yong-Won ko Choi, Kyu-Sil ko Min, Jeong-Ki ko Kim, Yun-Hee ko Suh, Pann-Ghill ko Kang, Kyung-Sun ko Won, Moo-Ho ko Kim, Young-Myeong ko Kwon, Young-Guen ko 2014-09-04T00:40:23Z - 2014-09-03 ko 2009-01 ko
dc.identifier.citation BLOOD, v.113, no.1, pp.233 - 243 ko
dc.identifier.issn 0006-4971 ko
dc.identifier.uri -
dc.description.abstract Homing of endothelial progenitor cells (EPCs) to the neovascular zone is now considered to be an essential step in the formation of vascular networks during embryonic development and also for neovascularization in postnatal life. We report here the prominent role of the insulinlike growth factor 2 (IGF2)/IGF2 receptor (IGF2R) system in promoting EPC homing. With high-level expression of IGF2R in EPCs, IGF2-induced hypoxic conditions stimulated multiple steps of EPC homing in vitro and promoted both EPC recruitment and incorporation into the neovascular area, resulting in enhanced angiogenesis in vivo. Remarkably, all IGF2 actions were exerted predominantly through IGF2R-linked G(i) protein signaling and required intracellular Ca2 + mobilization induced by the β 2 isoform of phospholipase C. Together, these findings indicate that locally generated IGF2 at either ischemic or tumor sites may contribute to postnatal vasculogenesis by augmenting the recruitment of EPCs. The utilization of the IGF2/IGF2R system may therefore be useful for the development of novel means to treat angiogenesisdependent diseases. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher AMER SOC HEMATOLOGY ko
dc.title Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLC beta 2 axis ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-59449088639 ko
dc.identifier.wosid 000262162800031 ko
dc.type.rims ART ko
dc.description.wostc 57 *
dc.description.scopustc 51 * 2015-05-06 * 2014-09-03 *
dc.identifier.doi 10.1182/blood-2008-06-162891 ko
dc.identifier.url ko
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