BROWSE

Related Researcher

Author's Photo

Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

ITEM VIEW & DOWNLOAD

Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLC beta 2 axis

DC Field Value Language
dc.contributor.author Maeng, Yong-Sun ko
dc.contributor.author Choi, Hyun-Jung ko
dc.contributor.author Kwon, Ja-Young ko
dc.contributor.author Park, Yong-Won ko
dc.contributor.author Choi, Kyu-Sil ko
dc.contributor.author Min, Jeong-Ki ko
dc.contributor.author Kim, Yun-Hee ko
dc.contributor.author Suh, Pann-Ghill ko
dc.contributor.author Kang, Kyung-Sun ko
dc.contributor.author Won, Moo-Ho ko
dc.contributor.author Kim, Young-Myeong ko
dc.contributor.author Kwon, Young-Guen ko
dc.date.available 2014-09-04T00:40:23Z -
dc.date.created 2014-09-03 ko
dc.date.issued 2009-01 ko
dc.identifier.citation BLOOD, v.113, no.1, pp.233 - 243 ko
dc.identifier.issn 0006-4971 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/5651 -
dc.description.abstract Homing of endothelial progenitor cells (EPCs) to the neovascular zone is now considered to be an essential step in the formation of vascular networks during embryonic development and also for neovascularization in postnatal life. We report here the prominent role of the insulinlike growth factor 2 (IGF2)/IGF2 receptor (IGF2R) system in promoting EPC homing. With high-level expression of IGF2R in EPCs, IGF2-induced hypoxic conditions stimulated multiple steps of EPC homing in vitro and promoted both EPC recruitment and incorporation into the neovascular area, resulting in enhanced angiogenesis in vivo. Remarkably, all IGF2 actions were exerted predominantly through IGF2R-linked G(i) protein signaling and required intracellular Ca2 + mobilization induced by the β 2 isoform of phospholipase C. Together, these findings indicate that locally generated IGF2 at either ischemic or tumor sites may contribute to postnatal vasculogenesis by augmenting the recruitment of EPCs. The utilization of the IGF2/IGF2R system may therefore be useful for the development of novel means to treat angiogenesisdependent diseases. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher AMER SOC HEMATOLOGY ko
dc.title Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLC beta 2 axis ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-59449088639 ko
dc.identifier.wosid 000262162800031 ko
dc.type.rims ART ko
dc.description.wostc 57 *
dc.description.scopustc 51 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-09-03 *
dc.identifier.doi 10.1182/blood-2008-06-162891 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=59449088639 ko
Appears in Collections:
BIO_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show simple item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU