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Suh, Pann-Ghill
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dc.citation.endPage 33840 -
dc.citation.number 49 -
dc.citation.startPage 33833 -
dc.citation.title JOURNAL OF BIOLOGICAL CHEMISTRY -
dc.citation.volume 284 -
dc.contributor.author Yea, Kyungmoo -
dc.contributor.author Kim, Jaeyoon -
dc.contributor.author Yoon, Jong Hyuk -
dc.contributor.author Kwon, Taewan -
dc.contributor.author Kim, Jong Hyun -
dc.contributor.author Lee, Byoung Dae -
dc.contributor.author Lee, Hae-Jeong -
dc.contributor.author Lee, Seung Jae -
dc.contributor.author Kim, Jong-In -
dc.contributor.author Lee, Taehoon G. -
dc.contributor.author Baek, Moon-Chang -
dc.contributor.author Park, Ho Seon -
dc.contributor.author Park, Kyong Soo -
dc.contributor.author Ohba, Motoi -
dc.contributor.author Suh, Pann-Ghill -
dc.contributor.author Ryu, Sung Ho -
dc.date.accessioned 2023-12-22T07:37:22Z -
dc.date.available 2023-12-22T07:37:22Z -
dc.date.created 2014-09-03 -
dc.date.issued 2009-12 -
dc.description.abstract Glucose homeostasis is maintained by the orchestration of peripheral glucose utilization and hepatic glucose production, mainly by insulin. In this study, we found by utilizing a combined parallel chromatography mass profiling approach that lysophosphatidylcholine (LPC) regulates glucose levels. LPC was found to stimulate glucose uptake in 3T3-L1 adipocytes dose- and time-dependently, and this activity was found to be sensitive to variations in acyl chain lengths and to polar head group types in LPC. Treatment with LPC resulted in a significant increase in the level of GLUT4 at the plasma membranes of 3T3-L1 adipocytes. Moreover, LPC did not affect IRS-1 and AKT2 phosphorylations, and LPC-induced glucose uptake was not influenced by pretreatment with the PI 3-kinase inhibitor LY294002. However, glucose uptake stimulation by LPC was abrogated both by rottlerin (a protein kinase Cδ inhibitor) and by the adenoviral expression of dominant negative protein kinase Cδ. In line with its determined cellular functions, LPC was found to lower blood glucose levels in normal mice. Furthermore, LPC improved blood glucose levels in mouse models of type 1 and 2 diabetes. These results suggest that an understanding of the mode of action of LPC may provide a new perspective of glucose homeostasis. -
dc.identifier.bibliographicCitation JOURNAL OF BIOLOGICAL CHEMISTRY, v.284, no.49, pp.33833 - 33840 -
dc.identifier.doi 10.1074/jbc.M109.024869 -
dc.identifier.issn 0021-9258 -
dc.identifier.scopusid 2-s2.0-71749095787 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/5646 -
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=71749095787 -
dc.identifier.wosid 000272165200015 -
dc.language 영어 -
dc.publisher AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC -
dc.title Lysophosphatidylcholine Activates Adipocyte Glucose Uptake and Lowers Blood Glucose Levels in Murine Models of Diabetes -
dc.type Article -
dc.description.journalRegisteredClass scopus -

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