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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Quercetin Suppresses HeLa Cell Viability via AMPK-Induced HSP70 and EGFR Down-Regulation

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dc.contributor.author Jung, Jin Hee ko
dc.contributor.author Lee, Jeong Ok ko
dc.contributor.author Kim, Ji Hae ko
dc.contributor.author Lee, Soo Kyung ko
dc.contributor.author You, Ga Young ko
dc.contributor.author Park, Sun Hwa ko
dc.contributor.author Park, Ji Man ko
dc.contributor.author Kim, Eung-Kyun ko
dc.contributor.author Suh, Pann-Ghill ko
dc.contributor.author An, Jin Kyung ko
dc.contributor.author Kim, Hyeon Soo ko
dc.date.available 2014-09-04T00:40:14Z -
dc.date.created 2014-09-03 ko
dc.date.issued 2010-05 ko
dc.identifier.citation JOURNAL OF CELLULAR PHYSIOLOGY, v.223, no.2, pp.408 - 414 ko
dc.identifier.issn 0021-9541 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/5644 -
dc.description.abstract Quercetin, an anti-oxidant flavonoid that is widely distributed in the plant kingdom, has been suggested to have chemopreventive effects on cancer cells, although the mechanism is not completely understood. In this study, we found that quercetin increased the phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) and suppressed the viability of HeLa cells. AICAR, an AMPK activator, and quercetin down-regulated heat shock protein (HSP)70 and increased the activity of the pro-apoptotic effector, caspase 3. Knock-down of AMPK blocked quercetin-mediated HSP70 down-regulation. Moreover, knock-down of HSP70 enhanced quercetin-mediated caspase 3 activation. Furthermore, quercetin sustained epidermal growth factor receptor (EGFR) activation by suppressing the phosphatases, PP2a and SHP-2. Finally, quercetin increased the interaction between EGFR and Cbl, and also induced the tyrosine phosphorylation of Cbl. Together, these results suggest that quercetin may have anti-tumor effects on HeLa cells via AMPK-induced HSP70 and down-regulation of EGFR. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher WILEY-BLACKWELL ko
dc.title Quercetin Suppresses HeLa Cell Viability via AMPK-Induced HSP70 and EGFR Down-Regulation ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-77950792403 ko
dc.identifier.wosid 000276428100016 ko
dc.type.rims ART ko
dc.description.wostc 32 *
dc.description.scopustc 34 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-09-03 *
dc.identifier.doi 10.1002/jcp.22049 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77950792403 ko
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