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Clustering of surface NMDA receptors is mainly mediated by the C-terminus of GluN2A in cultured rat hippocampal neurons

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dc.contributor.author Yan, Yinggang ko
dc.contributor.author Zhang, Jie ko
dc.contributor.author Xu, Shujun ko
dc.contributor.author Luo, Jianhong ko
dc.contributor.author Qiu, Shuang ko
dc.contributor.author Wang, Wei ko
dc.date.available 2014-09-04T00:39:53Z -
dc.date.created 2014-09-03 ko
dc.date.issued 2014-08 ko
dc.identifier.citation NEUROSCIENCE BULLETIN, v.30, no.4, pp.655 - 666 ko
dc.identifier.issn 1673-7067 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/5630 -
dc.description.abstract N-methyl-D-aspartate receptors (NMDARs) containing different GluN2 subunits play distinct roles in synaptic plasticity. Such differences may not only be determined by the channel properties, but also by differential surface distribution and synaptic localization. In the present study, using a Cy3-conjugated Fab fragment of the GFP antibody to label surface-located GluN2 subunits tagged with GFP at the N-terminus, we observed the membrane distribution patterns of GluN2A- or GluN2B-containing NMDARs in cultured rat hippocampal neurons. We found that surface NMDARs containing GluN2A, but not those containing GluN2B, were inclined to cluster at DIV7. Swapping the carboxyl termini of the GluN2 subunits completely reversed these distribution patterns. In addition, surface NMDARs containing GluN2A were preferentially associated with PSD-95. Taken together, the results of our study suggest that the clustering distribution of GluN2A-containing NMDARs is determined by the GluN2A C-terminus, and its interaction with PSD-95 plays an important role in this process. ko
dc.description.statementofresponsibility open -
dc.language 영어 ko
dc.publisher SPRINGER ko
dc.title Clustering of surface NMDA receptors is mainly mediated by the C-terminus of GluN2A in cultured rat hippocampal neurons ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84905997039 ko
dc.identifier.wosid 000340071400011 ko
dc.type.rims ART ko
dc.description.scopustc 1 *
dc.date.scptcdate 2014-09-03 *
dc.identifier.doi 10.1007/s12264-014-1450-8 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84905997039 ko
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