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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 2480 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2470 | - |
dc.citation.title | CELLULAR SIGNALLING | - |
dc.citation.volume | 26 | - |
dc.contributor.author | Koh, Ara | - |
dc.contributor.author | Park, Dohyun | - |
dc.contributor.author | Jeong, Heeyoon | - |
dc.contributor.author | Lee, Jiyoun | - |
dc.contributor.author | Lee, Mi Nam | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.date.accessioned | 2023-12-22T02:07:30Z | - |
dc.date.available | 2023-12-22T02:07:30Z | - |
dc.date.created | 2014-09-03 | - |
dc.date.issued | 2014-11 | - |
dc.description.abstract | C1-Ten is a member of the tensin family of focal adhesion molecules but recent studies suggest it plays a more active role in many biological processes because of its potential association with diabetes and cancers. However, relatively little is known about the regulation of C1-Ten, such as changes in its protein level or cellular localization. The cellular localization of C1-Ten is unique because it is expressed in cytoplasmic puncta but nothing is known about these puncta. Here, we show that p62 sequestrates C1-Ten into puncta, making C1-Ten diffuse into the cytoplasm upon p62 depletion. More importantly, p62-mediated C1-Ten sequestration promoted C1-Ten ubiquitination and proteasomal degradation. p62-mediated protein reduction was specific to C1-Ten, and not other tensins such as tensin1 and tensin3. Thus, our results link cellular localization of C1-Ten to an off-switch site for C1-Ten. Additionally, p62 expression increased but C1-Ten protein decreased during muscle differentiation, supporting a role for p62 as a physiological regulator of C1-Ten. | - |
dc.identifier.bibliographicCitation | CELLULAR SIGNALLING, v.26, no.11, pp.2470 - 2480 | - |
dc.identifier.doi | 10.1016/j.cellsig.2014.07.033 | - |
dc.identifier.issn | 0898-6568 | - |
dc.identifier.scopusid | 2-s2.0-84906061893 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/5627 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84906061893 | - |
dc.identifier.wosid | 000342717400019 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Regulation of C1-Ten protein tyrosine phosphatase by p62/SQSTM1-mediated sequestration and degradation | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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