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DC Field | Value | Language |
---|---|---|
dc.citation.number | 7 | - |
dc.citation.startPage | e20201763 | - |
dc.citation.title | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.citation.volume | 218 | - |
dc.contributor.author | Sasai, Miwa | - |
dc.contributor.author | Ma, Ji Su | - |
dc.contributor.author | Okamoto, Masaaki | - |
dc.contributor.author | Nishino, Kohei | - |
dc.contributor.author | Nagaoka, Hikaru | - |
dc.contributor.author | Takashima, Eizo | - |
dc.contributor.author | Pradipta, Ariel | - |
dc.contributor.author | Lee, Youngae | - |
dc.contributor.author | Kosako, Hidetaka | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Yamamoto, Masahiro | - |
dc.date.accessioned | 2023-12-21T15:39:26Z | - |
dc.date.available | 2023-12-21T15:39:26Z | - |
dc.date.created | 2021-07-15 | - |
dc.date.issued | 2021-07 | - |
dc.description.abstract | Because of their common signaling molecules, the main T cell receptor (TCR) signaling cascades in CD4(+) and CD8(+) T cells are considered qualitatively identical. Herein, we show that TCR signaling in CD8(+) T cells is qualitatively different from that in CD4(+) T cells, since CD8 alpha ignites another cardinal signaling cascade involving phospholipase C beta 4 (PLC beta 4). TCR-mediated responses were severely impaired in PLC beta 4-deficient CD8(+) T cells, whereas those in CD4(+) T cells were intact. PLC beta 4-deficient CD8(+) T cells showed perturbed activation of peripheral TCR signaling pathways downstream of IP3 generation. Binding of PLC beta 4 to the cytoplasmic tail of CD8 alpha was important for CD8(+) T cell activation. Furthermore, GNAQ interacted with PLC beta 4, mediated double phosphorylation on threonine 886 and serine 890 positions of PLC beta 4, and activated CD8(+) T cells in a PLC beta 4-dependent fashion. PLC beta 4-deficient mice exhibited defective antiparasitic host defense and antitumor immune responses. Altogether, PLC beta 4 differentiates TCR signaling in CD4(+) and CD8(+) T cells and selectively promotes CD8(+) T cell-dependent adaptive immunity. | - |
dc.identifier.bibliographicCitation | JOURNAL OF EXPERIMENTAL MEDICINE, v.218, no.7, pp.e20201763 | - |
dc.identifier.doi | 10.1084/jem.20201763 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.scopusid | 2-s2.0-85105723438 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/55932 | - |
dc.identifier.url | https://rupress.org/jem/article/218/7/e20201763/212085/Uncovering-a-novel-role-of-PLC-4-in-selectively | - |
dc.identifier.wosid | 000656304900007 | - |
dc.language | 영어 | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.title | Uncovering a novel role of PLC beta 4 in selectively mediating TCR signaling in CD8(+) but not CD4(+) T cells | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Immunology; Medicine, Research & Experimental | - |
dc.relation.journalResearchArea | Immunology; Research & Experimental Medicine | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | PHOSPHOLIPASE-C-BETA | - |
dc.subject.keywordPlus | PROTEIN ALPHA-SUBUNIT | - |
dc.subject.keywordPlus | TOXOPLASMA-GONDII | - |
dc.subject.keywordPlus | ANTIGEN RECEPTOR | - |
dc.subject.keywordPlus | TYROSINE PHOSPHORYLATION | - |
dc.subject.keywordPlus | CYTOPLASMIC DOMAINS | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | LCK | - |
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