File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

GrzybowskiBartosz Andrzej

Grzybowski, Bartosz A.
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Full metadata record

DC Field Value Language
dc.citation.endPage 11490 -
dc.citation.number 7 -
dc.citation.startPage 11470 -
dc.citation.title ACS NANO -
dc.citation.volume 15 -
dc.contributor.author Kolygina, Diana, V -
dc.contributor.author Siek, Marta -
dc.contributor.author Borkowska, Magdalena -
dc.contributor.author Ahumada, Guillermo -
dc.contributor.author Barski, Piotr -
dc.contributor.author Witt, Dariusz -
dc.contributor.author Jee, Ah-Young -
dc.contributor.author Miao, Han -
dc.contributor.author Ahumada, Juan Carlos -
dc.contributor.author Granick, Steve -
dc.contributor.author Kandere-Grzybowska, Kristiana -
dc.contributor.author Grzybowski, Bartosz A. -
dc.date.accessioned 2023-12-21T15:38:06Z -
dc.date.available 2023-12-21T15:38:06Z -
dc.date.created 2021-08-26 -
dc.date.issued 2021-07 -
dc.description.abstract Targeted delivery of molecular cargos to specific organelles is of paramount importance for developing precise and effective therapeutics and imaging probes. This work describes a disulfide-based delivery method in which mixed-charged nanoparticles traveling through the endolysosomal tract deliver noncovalently bound dye molecules selectively into mitochondria. This system comprises three elements: (1) The nanoparticles deliver their payloads by a kiss-and-go mechanism. that is, they drop off their dye cargos proximate to mitochondria but do not localize therein; (2) - the dye molecules are by themselves nonspecific to any cellular structures but become so with the help of mixed-charge nanocarriers; and (3) the dye is engineered in such a way as to remain in mitochondria for a long time, up to days, allowing for observing dynamic remodeling of mitochondrial networks and long-term tracking of mitochondria even in dividing cells. The selectivity of delivery and long-lasting staining derive from the ability to engineer charge-imbalanced, mixed [+/-] on-particle monolayers and from the structural features of the cargo. Regarding the former, the balance of [+] and [-] ligands can be adjusted to limit cytotoxicity and control the number of dye molecules adsorbed onto the particles' surfaces. Regarding the latter, comparative studies with multiple dye derivatives we synthesized rationalize the importance of polar groups, long alkyl chains, and disulfide moieties in the assembly of fluorescent nanoconstructs and long-lasting staining of mitochondria. Overall, this strategy could be useful for delivering hydrophilic and/or anionic small-molecule drugs difficult to target to mitochondria by classical approaches. -
dc.identifier.bibliographicCitation ACS NANO, v.15, no.7, pp.11470 - 11490 -
dc.identifier.doi 10.1021/acsnano.1c01232 -
dc.identifier.issn 1936-0851 -
dc.identifier.scopusid 2-s2.0-85110430084 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/55375 -
dc.identifier.url https://pubs.acs.org/doi/10.1021/acsnano.1c01232 -
dc.identifier.wosid 000679406500044 -
dc.language 영어 -
dc.publisher AMER CHEMICAL SOC -
dc.title Mixed-Charge Nanocarriers Allow for Selective Targeting of Mitochondria by Otherwise Nonselective Dyes -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary -
dc.relation.journalResearchArea Chemistry; Science & Technology - Other Topics; Materials Science -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor fluorescein disulfide -
dc.subject.keywordAuthor mitochondrial targeting -
dc.subject.keywordAuthor mixed-charge nanoparticles -
dc.subject.keywordAuthor nanocarriers -
dc.subject.keywordAuthor fluorescent probe -
dc.subject.keywordPlus CONJUGATION -
dc.subject.keywordPlus ABSORPTION -
dc.subject.keywordPlus ORGANELLES -
dc.subject.keywordPlus GOLD NANOPARTICLES -
dc.subject.keywordPlus CELLULAR UPTAKE -
dc.subject.keywordPlus FLUORESCENCE PROPERTIES -
dc.subject.keywordPlus LIGAND-EXCHANGE -
dc.subject.keywordPlus LIVING CELLS -
dc.subject.keywordPlus MEMBRANE -
dc.subject.keywordPlus THIOLS -

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.