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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1682 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1674 | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 53 | - |
dc.contributor.author | Lee, Byeong Eun | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Kim, Jae-Ick | - |
dc.date.accessioned | 2023-12-21T15:07:41Z | - |
dc.date.available | 2023-12-21T15:07:41Z | - |
dc.date.created | 2021-11-27 | - |
dc.date.issued | 2021-11 | - |
dc.description.abstract | O-GlcNAcylation is a posttranslational modification that adds O-linked β-N-acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins. This protein modification interacts with key cellular pathways involved in transcription, translation, and proteostasis. Although ubiquitous throughout the body, O-GlcNAc is particularly abundant in the brain, and various proteins commonly found at synapses are O-GlcNAcylated. Recent studies have demonstrated that the modulation of O-GlcNAc in the brain alters synaptic and neuronal functions. Furthermore, altered brain O-GlcNAcylation is associated with either the etiology or pathology of numerous neurodegenerative diseases, while the manipulation of O-GlcNAc exerts neuroprotective effects against these diseases. Although the detailed molecular mechanisms underlying the functional roles of O-GlcNAcylation in the brain remain unclear, O-GlcNAcylation is critical for regulating diverse neural functions, and its levels change during normal and pathological aging. In this review, we will highlight the functional importance of O-GlcNAcylation in the brain and neurodegenerative diseases. | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.53, no.11, pp.1674 - 1682 | - |
dc.identifier.doi | 10.1038/s12276-021-00709-5 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.scopusid | 2-s2.0-85119972435 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/54958 | - |
dc.identifier.url | https://www.nature.com/articles/s12276-021-00709-5 | - |
dc.identifier.wosid | 000722834300002 | - |
dc.language | 영어 | - |
dc.publisher | SPRINGERNATURE | - |
dc.title | O-GlcNAcylation in health and neurodegenerative diseases | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Medicine, Research & Experimental | - |
dc.identifier.kciid | ART002781246 | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Research & Experimental Medicine | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | LINKED N-ACETYLGLUCOSAMINEAMYOTROPHIC-LATERAL-SCLEROSISGLCNAC MODIFICATIONALPHA-SYNUCLEINNUCLEAR-POREPARKINSONS-DISEASETAU PATHOLOGYGLYCOSYLATIONNEURONSTRANSFERASE | - |
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