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Lee, Jiseok
Novel Optofluidic Materials Synthesis Lab
Research Interests
  • Optofluidic photolithography
  • Nanoparticle Synthesis
  • Conjugated polymer design and Synthesis
  • Flow lithography
  • 3d printing

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High-throughput investigation of complex cellular behavior in a mechanically-tunable 3D hydrogel co-culture system prepared via programmable multilayer printing

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dc.contributor.author Hong, Jisu ko
dc.contributor.author Shin, Yoonkyung ko
dc.contributor.author Lee, Jiseok ko
dc.contributor.author Cha, Chaenyung ko
dc.date.available 2021-11-25T08:09:08Z -
dc.date.created 2021-11-19 ko
dc.date.issued 2021-11-04 ko
dc.identifier.citation 2021 한국공업화학회 추계 학술대회 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/54912 -
dc.description.abstract Hydrogels are widely used as a 3D cell coculture platform, as they can be tailored to provide suitable microenvironments to induce cellular phenotypes with physiological significance. Herein, a mechanically- tunable 3D hydrogel-based co-culture system was fabricated via programmable multilayer photolithography in an efficient and scalable manner, which consists of a cell encapsulated inner microgel array and an outer hydrogel overlay. Through the high-throughput investigation of both individual hydrogel mechanics and mechanical gradients generated at their interface, it was demonstrated that macrophage phenotypical changes (i.e. proliferation, spheroid formation and Mϕ polarization) were substantially influenced by the direction and degree of mechanical gradient, as well as the presence of co-cultured fibro- blasts in the vicinity. Furthermore, the paracrine effect between the macrophages in different microgels was clearly mediated by their inter-distance. ko
dc.publisher 한국공업화학회 ko
dc.title High-throughput investigation of complex cellular behavior in a mechanically-tunable 3D hydrogel co-culture system prepared via programmable multilayer printing ko
dc.type CONFERENCE ko
dc.type.rims CONF ko
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