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Cha, Chaenyung
Integrative Biomaterials Engineering
Research Interests
  • Biopolymer, nanocomposites, microfabrication, tissue engineering, drug delivery

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Synergistic control of mechanics and microarchitecture of 3d hydrogel for engineering hepatic tissue

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dc.contributor.author Cha, Chaenyung ko
dc.date.available 2021-11-25T08:09:05Z -
dc.date.created 2021-11-19 ko
dc.date.issued 2021-11-15 ko
dc.identifier.citation 2021 TERMIS World Congress ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/54909 -
dc.description.abstract Culturing autologous cells with therapeutic potential derived from a patient within a bioactive scaffold to induce high functioning tissue formation is considered the ideal methodology towards realizing patient-specific regenerative medicine. Hydrogels are often employed as the scaffold material for this purpose mainly for their tunable mechanical and diffusional properties as well as presenting cell-responsive moieties. Herein, a two-fold strategy was employed to control the physicomechanical properties and microarchitecture of hydrogels to maximize the efficacy of engineered hepatic tissues. First, a hydrophilic polymeric crosslinker with a tunable degree of reactive functional groups was employed to control the mechanical properties in a wide range while minimizing the change in diffusional properties. Second, photolithography technique was utilized to introduce microchannels into hydrogels to overcome the critical diffusional limit of bulk hydrogels. Encapsulating hepatic progenitor cells derived via direct reprogramming of tissue-harvested fibroblasts, the applications of this strategy to control the mechanics, diffusion, and architecture of hydrogels in a combinatorial manner could maximize their hepatic functions. The regenerative capacity of this engineered hepatic tissue was further demonstrated using an in vivo acute liver injury model. ko
dc.language 영어 ko
dc.publisher Tissue Engineering and Regenerative Medicine International Society ko
dc.title Synergistic control of mechanics and microarchitecture of 3d hydrogel for engineering hepatic tissue ko
dc.type CONFERENCE ko
dc.type.rims CONF ko
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