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DC Field | Value | Language |
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dc.citation.number | 4 | - |
dc.citation.startPage | 0271678X21 | - |
dc.citation.title | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | - |
dc.citation.volume | 42 | - |
dc.contributor.author | Jang, MinJung | - |
dc.contributor.author | Han, SoHyun | - |
dc.contributor.author | Cho, Hyungjoon | - |
dc.date.accessioned | 2023-12-21T14:20:26Z | - |
dc.date.available | 2023-12-21T14:20:26Z | - |
dc.date.created | 2021-11-23 | - |
dc.date.issued | 2022-04 | - |
dc.description.abstract | Quantitative measurement of cerebrospinal fluid (CSF) flow and volume and longitudinal monitoring of CSF dynamics provide insights into the compensatory characteristics of post-stroke CSF. In this study, we compared the MRI pseudo-diffusion index (D*) of live and sacrificed rat brains to confirm the effect of ventricular CSF flow on diffusion signals. We observed the relationship between the CSF peak velocities and D* through Monte Carlo (MC) simulations to further understand the source of D* contrast. We also determined the dominant CSF flow using D* in three directions. Finally, we investigated the dynamic evolutions of ventricular CSF flow and volume in a stroke rat model (n = 8) from preoperative to up to 45 days after surgery and determined the correlation between ventricular CSF volume and flow. MC simulations showed a strong positive correlation between the CSF peak velocity and D* (r = 0.99). The dominant CSF flow variations in the 3D ventricle could be measured using the maximum D* map. A longitudinal positive correlation between ventricular CSF volume and D* was observed in the lateral (r = 0.74) and ventral-third (r = 0.81) ventricles, respectively. The directional D* measurements provide quantitative CSF volume and flow information, which would provide useful insights into ischemic stroke with diffusion MRI. | - |
dc.identifier.bibliographicCitation | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, v.42, no.4, pp.0271678X21 | - |
dc.identifier.doi | 10.1177/0271678X211060741 | - |
dc.identifier.issn | 0271-678X | - |
dc.identifier.scopusid | 2-s2.0-85119621783 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/54870 | - |
dc.identifier.url | https://journals.sagepub.com/doi/10.1177/0271678X211060741 | - |
dc.identifier.wosid | 000721951100001 | - |
dc.language | 영어 | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.title | D* from diffusion MRI reveals a correspondence between ventricular cerebrospinal fluid volume and flow in the ischemic rodent model | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & MetabolismHematologyNeurosciences | - |
dc.relation.journalResearchArea | Endocrinology & MetabolismHematologyNeurosciences & Neurology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Cerebrospinal fluid volumecerebrospinal fluid flowdiffusion MRIsubacute stageischemic stroke | - |
dc.subject.keywordPlus | CEREBRAL EDEMACHOROID-PLEXUSINFARCT VOLUMESTROKEQUANTIFICATIONBIOMARKERPATTERNSAQUEDUCT | - |
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