Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 267 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 251 | - |
dc.citation.title | Journal of Lipid and Atherosclerosis | - |
dc.citation.volume | 10 | - |
dc.contributor.author | Park, Sung Ho | - |
dc.date.accessioned | 2023-12-21T15:15:28Z | - |
dc.date.available | 2023-12-21T15:15:28Z | - |
dc.date.created | 2021-10-13 | - |
dc.date.issued | 2021-09 | - |
dc.description.abstract | Chronic inflammation is a hallmark of atherosclerosis and macrophages play a central role in controlling inflammation at all stages of atherosclerosis. In atherosclerosis, macrophages and monocyte-derived macrophages are continuously exposed to cholesterol, oxidized lipids, cell debris, cytokines, and chemokines. Not only do these stimuli induce a specific macrophage phenotype, but they also interact extensively, leading to macrophage heterogeneity in atherosclerotic plaques. Herein, we review the diverse phenotypes of macrophages, the mechanisms underlying macrophage activation, and the contributions of macrophages to atherosclerosis in this context. We also summarize recent studies on foamy macrophages and monocyte-derived macrophages in plaque during disease progression. We provide a comprehensive overview of transcriptional, epigenetic, and metabolic reprogramming of macrophages and discuss the emerging concepts of targeting cytokines and macrophages to modulate atherosclerosis. | - |
dc.identifier.bibliographicCitation | Journal of Lipid and Atherosclerosis, v.10, no.3, pp.251 - 267 | - |
dc.identifier.doi | 10.12997/jla.2021.10.3.251 | - |
dc.identifier.issn | 2287-2892 | - |
dc.identifier.scopusid | 2-s2.0-85118505017 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/54122 | - |
dc.language | 영어 | - |
dc.publisher | 한국지질동맥경화학회 | - |
dc.title.alternative | Regulation of Macrophage Activation and Differentiation in Atherosclerosis | - |
dc.title | Regulation of Macrophage Activation and Differentiation in Atherosclerosis | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.identifier.kciid | ART002756012 | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordAuthor | Macrophage activation | - |
dc.subject.keywordAuthor | Cytokines | - |
dc.subject.keywordAuthor | Innate immune memory | - |
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