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Lim, Chunghun
Neurogenetics & Ribonomics Laboratory (The Lim Lab)
Research Interests
  • Ribosome Biology, Translation, Neurodegeneration, Behavioral Genetics


The trinity of ribosome-associated quality control and stress signaling for proteostasis and neuronal physiology

DC Field Value Language Park, Jumin ko Park, Jongmin ko Lee, Jongbin ko Lim, Chunghun ko 2021-10-01T01:42:50Z - 2021-09-30 ko 2021-09 ko
dc.identifier.citation BMB REPORTS, v.54, no.9, pp.439 - 450 ko
dc.identifier.issn 1976-6696 ko
dc.identifier.uri -
dc.description.abstract Translating ribosomes accompany co-translational regulation of nascent polypeptide chains, including subcellular targeting, protein folding, and covalent modifications. Ribosome-associated quality control (RQC) is a co-translational surveillance mechanism triggered by ribosomal collisions, an indication of atypical translation. The ribosome-associated E3 ligase ZNF598 ubiquitinates small subunit proteins at the stalled ribosomes. A series of RQC factors are then recruited to dissociate and triage aberrant translation intermediates. Regulatory ribosomal stalling may occur on endogenous transcripts for quality gene expression, whereas ribosomal collisions are more globally induced by ribotoxic stressors such as translation inhibitors, ribotoxins, and UV radiation. The latter are sensed by ribosome-associated kinases GCN2 and ZAKa, activating integrated stress response (ISR) and ribotoxic stress response (RSR), respectively. Hierarchical crosstalks among RQC, ISR, and RSR pathways are readily detectable since the collided ribosome is their common substrate for activation. Given the strong implications of RQC factors in neuronal physiology and neurological disorders, the interplay between RQC and ribosome-associated stress signaling may sustain proteostasis, adaptively deterrnine cell fate, and contribute to neural pathogenesis. The elucidation of underlying molecular principles in relevant human diseases should thus provide unexplored therapeutic opportunities. ko
dc.language 영어 ko
dc.title The trinity of ribosome-associated quality control and stress signaling for proteostasis and neuronal physiology ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85116326596 ko
dc.identifier.wosid 000703578200001 ko
dc.type.rims ART ko
dc.identifier.doi 10.5483/BMBRep.2021.54.9.097 ko
dc.identifier.url ko
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