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Park, Sung Ho
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Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets

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dc.contributor.author Lee, Jeong Seok ko
dc.contributor.author Koh, June-Young ko
dc.contributor.author Yi, Kijong ko
dc.contributor.author Kim, Young-Il ko
dc.contributor.author Park, Su-Jin ko
dc.contributor.author Kim, Eun-Ha ko
dc.contributor.author Kim, Se-Mi ko
dc.contributor.author Park, Sung Ho ko
dc.contributor.author Ju, Young Seok ko
dc.contributor.author Choi, Young Ki ko
dc.contributor.author Park, Su-Hyung ko
dc.date.available 2021-09-09T08:40:54Z -
dc.date.created 2021-09-08 ko
dc.date.issued 2021-07 ko
dc.identifier.citation NATURE COMMUNICATIONS, v.12, no.1, pp.4567 ko
dc.identifier.issn 2041-1723 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/53863 -
dc.description.abstract Few studies have used a longitudinal approach to describe the immune response to SARS-CoV-2 infection. Here, we perform single-cell RNA sequencing of bronchoalveolar lavage fluid cells longitudinally obtained from SARS-CoV-2-infected ferrets. Landscape analysis of the lung immune microenvironment shows distinct changes in cell proportions and characteristics compared to uninfected control, at 2 and 5 days post-infection (dpi). Macrophages are classified into 10 distinct subpopulations with transcriptome changes among monocyte-derived infiltrating macrophages and differentiated M1/M2 macrophages, notably at 2 dpi. Moreover, trajectory analysis reveals gene expression changes from monocyte-derived infiltrating macrophages toward M1 or M2 macrophages and identifies a macrophage subpopulation that has rapidly undergone SARS-CoV-2-mediated activation of inflammatory responses. Finally, we find that M1 or M2 macrophages show distinct patterns of gene modules downregulated by immune-modulatory drugs. Overall, these results elucidate fundamental aspects of the immune response dynamics provoked by SARS-CoV-2 infection. A longitudinal analysis of SARS-CoV-2 infection in humans is challenging. Here the authors show a single cell RNA-sequencing analysis of BAL fluid cells from ferrets and characterise the time dependent recruitment of macrophage subsets to the lungs in response to SARS-CoV-2 infection. ko
dc.language 영어 ko
dc.publisher NATURE PORTFOLIO ko
dc.title Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85111612748 ko
dc.identifier.wosid 000683367300030 ko
dc.type.rims ART ko
dc.identifier.doi 10.1038/s41467-021-24807-0 ko
dc.identifier.url https://www.nature.com/articles/s41467-021-24807-0 ko
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