File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Full metadata record

DC Field Value Language
dc.citation.endPage 2130 -
dc.citation.number 10 -
dc.citation.startPage 2122 -
dc.citation.title CELLULAR SIGNALLING -
dc.citation.volume 26 - Park, Dohyun - Lee, Mi Nam - Jeong, Heeyoon - Koh, Ara - Yang, Yong Ryoul - Suh, Pann-Ghill - Ryu, Sung Ho - 2023-12-22T02:10:36Z - 2023-12-22T02:10:36Z - 2014-08-07 - 2014-10 -
dc.description.abstract mTORC1, a kinase complex that is considered a master regulator of cellular growth and proliferation, is regulated by many extra- and intracellular signals. Among these signals, mitochondrial status is known to have an impact on the effects of mTORC1 on cell growth and survival. However, how mitochondrial status affects mTORC1 activity, notably the molecular link, is not fully elucidated. Here, we found that Parkin can interact with and ubiquitinate mTOR. We also identified K2066 and K2306 as Parkin-dependent and mitochondrial stress-induced mTOR ubiquitination residues. This ubiquitination by Parkin is required for maintenance of mTORC1 activity under mitochondrial stress. With regard to the physiological meaning of mTORC1 activity under mitochondrial stress, we suggest that mTORC1 plays a pro-survival role. -
dc.identifier.bibliographicCitation CELLULAR SIGNALLING, v.26, no.10, pp.2122 - 2130 -
dc.identifier.doi 10.1016/j.cellsig.2014.06.010 -
dc.identifier.issn 0898-6568 -
dc.identifier.scopusid 2-s2.0-84904430677 -
dc.identifier.uri -
dc.identifier.url -
dc.identifier.wosid 000340983200006 -
dc.language 영어 -
dc.title Parkin ubiquitinates mTOR to regulate mTORC1 activity under mitochondrial stress -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Cell Biology -
dc.relation.journalResearchArea Cell Biology -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -


Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.