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DC Field | Value | Language |
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dc.citation.endPage | 235 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 226 | - |
dc.citation.title | MEDICINAL CHEMISTRY RESEARCH | - |
dc.citation.volume | 30 | - |
dc.contributor.author | Abid, Obaid-ur-Rahman | - |
dc.contributor.author | Daud, Saima | - |
dc.contributor.author | Sardar, Asma | - |
dc.contributor.author | Rehman, Wajid | - |
dc.contributor.author | Wadood, Abdul | - |
dc.contributor.author | Rehman, Ashfaq Ur | - |
dc.contributor.author | Akhter, Toheed | - |
dc.contributor.author | Bibi, Iram | - |
dc.contributor.author | Ahmad, Zaheer | - |
dc.contributor.author | Yasir, Muhammad | - |
dc.date.accessioned | 2023-12-21T16:36:48Z | - |
dc.date.available | 2023-12-21T16:36:48Z | - |
dc.date.created | 2020-11-12 | - |
dc.date.issued | 2021-01 | - |
dc.description.abstract | A series of piperonal-based imines (3a-c) and bis-imines (5a-o) have been synthesized in search of new urease inhibitors. Synthesized compounds were characterized by H-1 NMR, C-13 NMR and EI-MS. These derivatives were subjected to evaluation of urease inhibitory potential, which exhibited a varied degree of potential, ranging from 41.7 +/- 5.8 to 353.6 +/- 5.8 mu M, when compared with the standard inhibitor (i.e., thiourea having IC50 value 21.8 +/- 1.51 mu M). Amongst the synthesized bis-imines, three compounds 5d, 5h, and 5g exhibited good inhibitory potential having IC50 values 41.7 +/- 5.8, 43.7 +/- 5.8, and 52.6 +/- 5.8 respectively so can be further investigated. The remaining compounds exhibited moderate to weak activities. Molecular modeling studies were performed to understand the binding interactions with the enzyme. | - |
dc.identifier.bibliographicCitation | MEDICINAL CHEMISTRY RESEARCH, v.30, no.1, pp.226 - 235 | - |
dc.identifier.doi | 10.1007/s00044-020-02651-z | - |
dc.identifier.issn | 1054-2523 | - |
dc.identifier.scopusid | 2-s2.0-85094646453 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/52855 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00044-020-02651-z | - |
dc.identifier.wosid | 000583138800001 | - |
dc.language | 영어 | - |
dc.publisher | SPRINGER BIRKHAUSER | - |
dc.title | Synthesis, urease inhibition screening and molecular docking studies of piperonal based imine derivatives | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Urease inhibition | - |
dc.subject.keywordAuthor | Molecular modeling studies | - |
dc.subject.keywordAuthor | Piperonal | - |
dc.subject.keywordAuthor | Diamines | - |
dc.subject.keywordAuthor | bis-imines | - |
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