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Kwon, Tae-Hyuk
Energy Recognition
Research Interests
  • Energy transfer, organic solar cells, supercapacitor, ultrasonic spray chemistry, dithienothiophene, iridium complexes, phosphorescent bioapplications


Phosphorescent sensor for phosphorylated peptides based on an iridium complex

DC Field Value Language Kang, Jung Hyun ko Kim, Hee Jin ko Kwon, Tae-Hyuk ko Hong, Jong-In ko 2014-07-30T05:43:19Z - 2014-07-30 ko 2014-07 ko
dc.identifier.citation JOURNAL OF ORGANIC CHEMISTRY, v.79, no.13, pp.6000 - 6005 ko
dc.identifier.issn 0022-3263 ko
dc.identifier.uri -
dc.description.abstract A bis[(4,6-difluorophenyl)pyridinato-N,C2']iridium(III) picolinate (FIrpic) derivative coupled with bis(Zn2+-dipicolylamine) (ZnDPA) was developed as a sensor (1) for phosphorylated peptides, which are related to many cellular mechanisms. As a control, a fluorescent sensor (2) based on anthracene coupled to ZnDPA was also prepared. When the total negative charge on the phosphorylated peptides was changed to -2, -4, and -6, the emission intensity of sensor 1 gradually increased by factors of up to 7, 11, and 16, respectively. In contrast, there was little change in the emission intensity of sensor 1 upon the addition of a neutral phosphorylated peptide, non-phosphorylated peptides, or various anions such as CO3 2-, NO3 -, SO4 2-, phosphate, azide, and pyrophosphate. Furthermore, sensor 1 could be used to visually discriminate between phosphorylated peptides and adenosine triphosphate in aqueous solution under a UV-vis lamp, unlike fluorescent sensor 2. This enhanced luminance of phosphorescent sensor 1 upon binding to a phosphorylated peptide is attributed to a reduction in the repulsion between the Zn 2+ ions due to the phenoxy anion, its strong metal-to-ligand charge transfer character, and a reduction in self-quenching. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher AMER CHEMICAL SOC ko
dc.title Phosphorescent sensor for phosphorylated peptides based on an iridium complex ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84903708377 ko
dc.identifier.wosid 000338693300007 ko
dc.type.rims ART ko
dc.description.wostc 1 *
dc.description.scopustc 0 * 2015-05-06 * 2014-07-30 *
dc.identifier.doi 10.1021/jo5005263 ko
dc.identifier.url ko
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