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Kwon, Tae-Hyuk
Energy Recognition
Research Interests
  • Energy transfer, organic solar cells, supercapacitor, ultrasonic spray chemistry, dithienothiophene, iridium complexes, phosphorescent bioapplications

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Phosphorescent sensor for phosphorylated peptides based on an iridium complex

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dc.contributor.author Kang, Jung Hyun ko
dc.contributor.author Kim, Hee Jin ko
dc.contributor.author Kwon, Tae-Hyuk ko
dc.contributor.author Hong, Jong-In ko
dc.date.available 2014-07-30T05:43:19Z -
dc.date.created 2014-07-30 ko
dc.date.issued 2014-07 ko
dc.identifier.citation JOURNAL OF ORGANIC CHEMISTRY, v.79, no.13, pp.6000 - 6005 ko
dc.identifier.issn 0022-3263 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/5275 -
dc.description.abstract A bis[(4,6-difluorophenyl)pyridinato-N,C2']iridium(III) picolinate (FIrpic) derivative coupled with bis(Zn2+-dipicolylamine) (ZnDPA) was developed as a sensor (1) for phosphorylated peptides, which are related to many cellular mechanisms. As a control, a fluorescent sensor (2) based on anthracene coupled to ZnDPA was also prepared. When the total negative charge on the phosphorylated peptides was changed to -2, -4, and -6, the emission intensity of sensor 1 gradually increased by factors of up to 7, 11, and 16, respectively. In contrast, there was little change in the emission intensity of sensor 1 upon the addition of a neutral phosphorylated peptide, non-phosphorylated peptides, or various anions such as CO3 2-, NO3 -, SO4 2-, phosphate, azide, and pyrophosphate. Furthermore, sensor 1 could be used to visually discriminate between phosphorylated peptides and adenosine triphosphate in aqueous solution under a UV-vis lamp, unlike fluorescent sensor 2. This enhanced luminance of phosphorescent sensor 1 upon binding to a phosphorylated peptide is attributed to a reduction in the repulsion between the Zn 2+ ions due to the phenoxy anion, its strong metal-to-ligand charge transfer character, and a reduction in self-quenching. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher AMER CHEMICAL SOC ko
dc.title Phosphorescent sensor for phosphorylated peptides based on an iridium complex ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84903708377 ko
dc.identifier.wosid 000338693300007 ko
dc.type.rims ART ko
dc.description.wostc 1 *
dc.description.scopustc 0 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-07-30 *
dc.identifier.doi 10.1021/jo5005263 ko
dc.identifier.url https://pubs.acs.org/doi/10.1021/jo5005263 ko
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