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Hong, Sung You
Synthetic Organic Chemistry Laboratory
Research Interests
  • Synthetic organic chemistry, transition metals, oxidation state

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Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting

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dc.contributor.author Bernardes, Goncalo J. L. ko
dc.contributor.author Kikkeri, Raghavendra ko
dc.contributor.author Maglinao, Maha ko
dc.contributor.author Laurino, Paola ko
dc.contributor.author Collot, Mayeul ko
dc.contributor.author Hong, Sung You ko
dc.contributor.author Lepenies, Bernd ko
dc.contributor.author Seeberger, Peter H. ko
dc.date.available 2014-07-30T00:26:11Z -
dc.date.created 2014-07-29 ko
dc.date.issued 2010-11 ko
dc.identifier.citation ORGANIC & BIOMOLECULAR CHEMISTRY, v.8, no.21, pp.4987 - 4996 ko
dc.identifier.issn 1477-0520 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/5246 -
dc.description.abstract Targeting glycan-binding receptors is an attractive strategy for cell-specific drug and gene delivery. The C-type lectin asialoglycoprotein receptor (ASGPR) is particularly suitable for liver-specific delivery due to its exclusive expression by parenchymal hepatocytes. In this study, we designed and developed an efficient synthesis of carbohydrate-functionalized beta-cyclodextrins (beta CDs) and liposomes for hepatocyte-specific delivery. For targeting of ASGPR, rhodamine B-loaded beta CDs were functionalized with glycodendrimers. Liposomes were equipped with synthetic glycolipids containing a terminal D-GalNAc residue to mediate binding to ASGPR. Uptake studies in the human hepatocellular carcinoma cell line HepG2 demonstrated that beta CDs and liposomes displaying terminal D-Gal/D-GalNAc residues were preferentially endocytosed. In contrast, uptake of beta CDs and liposomes with terminal D-Man or D-GlcNAc residues was markedly reduced. The D-Gal/D-GalNAcfunctionalized beta CDs and liposomes presented here enable hepatocyte-specific targeting. Gal-functionalized beta CDs are efficient molecular carriers to deliver doxorubicin in vitro into hepatocytes and induce apoptosis. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher ROYAL SOC CHEMISTRY ko
dc.title Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-77957899290 ko
dc.identifier.wosid 000282872600031 ko
dc.type.rims ART ko
dc.description.wostc 30 *
dc.description.scopustc 30 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-07-29 *
dc.identifier.doi 10.1039/c0ob00372g ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77957899290 ko
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