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DC Field | Value | Language |
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dc.citation.endPage | 4996 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 4987 | - |
dc.citation.title | ORGANIC & BIOMOLECULAR CHEMISTRY | - |
dc.citation.volume | 8 | - |
dc.contributor.author | Bernardes, Goncalo J. L. | - |
dc.contributor.author | Kikkeri, Raghavendra | - |
dc.contributor.author | Maglinao, Maha | - |
dc.contributor.author | Laurino, Paola | - |
dc.contributor.author | Collot, Mayeul | - |
dc.contributor.author | Hong, Sung You | - |
dc.contributor.author | Lepenies, Bernd | - |
dc.contributor.author | Seeberger, Peter H. | - |
dc.date.accessioned | 2023-12-22T06:40:51Z | - |
dc.date.available | 2023-12-22T06:40:51Z | - |
dc.date.created | 2014-07-29 | - |
dc.date.issued | 2010-11 | - |
dc.description.abstract | Targeting glycan-binding receptors is an attractive strategy for cell-specific drug and gene delivery. The C-type lectin asialoglycoprotein receptor (ASGPR) is particularly suitable for liver-specific delivery due to its exclusive expression by parenchymal hepatocytes. In this study, we designed and developed an efficient synthesis of carbohydrate-functionalized beta-cyclodextrins (beta CDs) and liposomes for hepatocyte-specific delivery. For targeting of ASGPR, rhodamine B-loaded beta CDs were functionalized with glycodendrimers. Liposomes were equipped with synthetic glycolipids containing a terminal D-GalNAc residue to mediate binding to ASGPR. Uptake studies in the human hepatocellular carcinoma cell line HepG2 demonstrated that beta CDs and liposomes displaying terminal D-Gal/D-GalNAc residues were preferentially endocytosed. In contrast, uptake of beta CDs and liposomes with terminal D-Man or D-GlcNAc residues was markedly reduced. The D-Gal/D-GalNAcfunctionalized beta CDs and liposomes presented here enable hepatocyte-specific targeting. Gal-functionalized beta CDs are efficient molecular carriers to deliver doxorubicin in vitro into hepatocytes and induce apoptosis. | - |
dc.identifier.bibliographicCitation | ORGANIC & BIOMOLECULAR CHEMISTRY, v.8, no.21, pp.4987 - 4996 | - |
dc.identifier.doi | 10.1039/c0ob00372g | - |
dc.identifier.issn | 1477-0520 | - |
dc.identifier.scopusid | 2-s2.0-77957899290 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/5246 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77957899290 | - |
dc.identifier.wosid | 000282872600031 | - |
dc.language | 영어 | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | ASIALOGLYCOPROTEIN RECEPTOR | - |
dc.subject.keywordPlus | GENE-TRANSFER | - |
dc.subject.keywordPlus | BETA-CYCLODEXTRIN | - |
dc.subject.keywordPlus | TERMINAL ALKYNES | - |
dc.subject.keywordPlus | FACILE SYNTHESIS | - |
dc.subject.keywordPlus | DC-SIGN | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | LECTIN | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
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