dc.citation.conferencePlace |
KO |
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dc.citation.conferencePlace |
Seoul, Korea |
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dc.citation.title |
KSBMB 62nd Annual Meeting |
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dc.contributor.author |
Kim YH |
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dc.contributor.author |
Shin KJ |
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dc.contributor.author |
Lee TG |
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dc.contributor.author |
Kim E |
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dc.contributor.author |
Lee MS |
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dc.contributor.author |
Ryu SH |
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dc.contributor.author |
Suh, Pann-Ghill |
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dc.date.accessioned |
2023-12-20T05:36:41Z |
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dc.date.available |
2023-12-20T05:36:41Z |
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dc.date.created |
2014-12-23 |
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dc.date.issued |
2005-05-19 |
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dc.description.abstract |
We screened a library of 11,000 small molecular weight chemicals, looking for compounds that affect cell viability. We have identified 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS) as a potent cytotoxic compound that induces cell cycle arrest and apoptosis. Treatment of Jurkat T cells with QBS increased the levels of cyclin B1 as well as phosphorylated-cdc2, which was accompanied by reduced activity of cdc2 kinase, suggesting that QBS may induce cell cycle arrest at G2 phase. Structural analogues of QBS also exhibited similar effects on cell cycle progression and cell viability. Long-term treatment with QBS resulted in DNA fragmentation, cytochrome C release, and PARP cleavage, and an increase in the number of subdiploidy cells, indicative of cellular apoptosis. Moreover, QBS-induced apoptosis was blocked by z-VAD-fmk, a pan-caspase inhibitor. These results suggest that QBS is a novel and potent compound that induces G2 arrest and subsequent apoptosis, implicating it as a putative candidate for chemotherapy. |
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dc.identifier.bibliographicCitation |
KSBMB 62nd Annual Meeting |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/52045 |
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dc.publisher |
생화학분자생물학회 |
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dc.title |
G2 arrest and apoptosis by QBS, a novel cytotoxic compound |
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dc.type |
Conference Paper |
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dc.date.conferenceDate |
2005-05-19 |
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