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Park, Jiyoung
Molecular Metabolism Laboratory (MML)
Research Interests
  • Obesity, diabetes, adipose tissue, cancer, cancer-associated adipocyte, dermal adipocyte, metabolic memory

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ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue

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Title
ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue
Author
Kim, MinNeinast, Michael D.Frank, Aaron P.Sun, KaiPark, JiyoungZehr, Jordan A.Vishvanath, LavanyaMorselli, EugeniaAmelotte, MasonPalmer, Biff F.Gupta, Rana K.Scherer, Philipp E.Clegg, Deborah J.
Issue Date
2014-09
Publisher
Elsevier GmbH
Citation
MOLECULAR METABOLISM, v.3, no.6, pp.642 - 651
Abstract
Hypoxia Inducible Factor 1 (HIF-1) promotes fibrosis and inflammation in adipose tissues, while estrogens and Estrogen Receptor α (ERα) have the opposite effect. Here we identify an Estrogen Response Element (ERE) in the promoter of Phd3, which is a negative regulatory enzyme of HIF-1, and we demonstrate HIF-1α is ubiquitinated following 17-β estradiol (E2)/ERα mediated Phd3 transcription. Manipulating ERα in vivo increases Phd3 transcription and reduces HIF-1 activity, while addition of PHD3 ameliorates adipose tissue fibrosis and inflammation. Our findings outline a novel regulatory relationship between E2/ERα, PHD3 and HIF-1 in adipose tissues, providing a mechanistic explanation for the protective effect of E2/ERα in adipose tissue.
URI
https://scholarworks.unist.ac.kr/handle/201301/5171
DOI
10.1016/j.molmet.2014.05.007
ISSN
2212-8778
Appears in Collections:
SLS_Journal Papers
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