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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C


CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice

DC Field Value Language Kim, Dayea ko Kim, Jaeyoon ko Yoon, Jong Hyuk ko Ghim, Jaewang ko Yea, Kyungmoo ko Song, Parkyong ko Park, Soyeon ko Lee, Areum ko Hong, Chun-Pyo ko Jang, Min Seong ko Kwon, Yonghoon ko Park, Sehoon ko Jang, Myoung Ho ko Berggren, Per-Olof ko Suh, Pann-Ghill ko Ryu, Sung Ho ko 2014-06-24T02:50:56Z - 2014-06-23 ko 2014-07 ko
dc.identifier.citation DIABETOLOGIA, v.57, no.7, pp.1456 - 1465 ko
dc.identifier.issn 0012-186X ko
dc.identifier.uri -
dc.description.abstract Aims/hypothesis Obesity-induced inflammation is initiated by the recruitment of macrophages into adipose tissue. The recruited macrophages, called adipose tissue macrophages, secrete several proinflammatory cytokines that cause low-grade systemic inflammation and insulin resistance. The aim of this study was to find macrophage-recruiting factors that are thought to provide a crucial connection between obesity and insulin resistance. Methods We used chemotaxis assay, reverse phase HPLC and tandem MS analysis to find chemotactic factors from adipocytes. The expression of chemokines and macrophage markers was evaluated by quantitative RT-PCR, immunohistochemistry and FACS analysis. Results We report our finding that the chemokine (C-X-C motif) ligand 12 (CXCL12, also known as stromal cell-derived factor 1), identified from 3T3-L1 adipocyte conditioned medium, induces monocyte migration via its receptor chemokine (C-X-C motif) receptor 4 (CXCR4). Diet-induced obese mice demonstrated a robust increase of CXCL12 expression in white adipose tissue (WAT). Treatment of obese mice with a CXCR4 antagonist reduced macrophage accumulation and production of proinflammatory cytokines in WAT, and improved systemic insulin sensitivity. Conclusions/interpretation In this study we found that CXCL12 is an adipocyte-derived chemotactic factor that recruits macrophages, and that it is a required factor for the establishment of obesity-induced adipose tissue inflammation and systemic insulin resistance. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher SPRINGER ko
dc.title CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84903531205 ko
dc.identifier.wosid 000337498700024 ko
dc.type.rims ART ko
dc.description.wostc 1 *
dc.description.scopustc 0 * 2015-05-06 * 2014-06-23 *
dc.identifier.doi 10.1007/s00125-014-3237-5 ko
dc.identifier.url ko
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