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Choi, Sung-Deuk
Environmental Analytical Chemistry Lab (EACL)
Research Interests
  • Persistent organic pollutants, Environmental Analysis and monitoring, Multimedia modeling, Fine particle

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Factors associated with partitioning behavior of persistent organic pollutants in a feto-maternal system: A multiple linear regression approach

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dc.contributor.author Kim, Jun-Tae ko
dc.contributor.author Oh, Dasom ko
dc.contributor.author Choi, Sung-Deuk ko
dc.contributor.author Chang, Yoon-Seok ko
dc.date.available 2021-02-25T08:47:52Z -
dc.date.created 2021-02-19 ko
dc.date.issued 2021-01 ko
dc.identifier.citation CHEMOSPHERE, v.263, pp.128247 ko
dc.identifier.issn 0045-6535 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/50041 -
dc.description.abstract Prenatal exposure to persistent organic pollutants (POPs) has been a matter of particular concern because such exposure can severely affect the health of the fetus. The mechanistic understanding of the partitioning behavior of POPs in the feto-maternal system and the associated factors, however, have rarely been studied. Here, we employed a new approach based on multiple linear regression (MLR) analysis to predict the feto-maternal ratio (FM-ratio) of POPs and to assess the factors associated with feto-maternal partitioning behavior. Two preliminary exploratory MLR models were built using physiological conditions of the participants, and molecular descriptors were calculated with a computational model. The FM-ratio was calculated from the concentrations of polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs), and polybrominated diphenyl ethers (PBDEs) in 20 pairs of maternal and cord blood. The models showed that the lipids and cholesterols in the maternal and cord blood and the placenta significantly influence the partitioning of POPs. The body mass index (BMI) change during pregnancy was also related to the FM-ratio. The physicochemical properties associated with lipophilicity and molecular size were also related to the FM-ratio. Even though the results should be interpreted with caution, the preliminary MLR models illustrate that feto-maternal partitioning is governed by transplacental transporting mechanisms, toxicokinetics, and the molecular physicochemical properties of POPs. Overall, the new approach used in this study can improve our understanding of the partitioning behavior in the feto-maternal system. (C) 2020 Published by Elsevier Ltd. ko
dc.language 영어 ko
dc.publisher PERGAMON-ELSEVIER SCIENCE LTD ko
dc.title Factors associated with partitioning behavior of persistent organic pollutants in a feto-maternal system: A multiple linear regression approach ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85091120848 ko
dc.identifier.wosid 000595802200300 ko
dc.type.rims ART ko
dc.identifier.doi 10.1016/j.chemosphere.2020.128247 ko
dc.identifier.url https://www.sciencedirect.com/science/article/pii/S0045653520324425?via%3Dihub ko
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