File Download

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Full metadata record

DC Field Value Language
dc.citation.number 1 -
dc.citation.startPage 8813 -
dc.citation.title SCIENTIFIC REPORTS -
dc.citation.volume 10 - Hong, Joohyeon - Ha, Go Eun - Kwak, Hankyul - Lee, Yelin - Jeong, Hyeonyeong - Suh, Pann-Ghill - Cheong, Eunji - 2023-12-21T17:20:58Z - 2023-12-21T17:20:58Z - 2020-07-06 - 2020-06 -
dc.description.abstract Sleep abnormality often accompanies the impairment of cognitive function. Both rapid eye movement (REM) and non-REM (NREM) sleep have associated with improved memory performance. However, the role of composition in NREM sleep, consisting of light and deep NREM, for memory formation is not fully understood. We investigated how the dynamics of NREM sleep states influence memory consolidation. Thalamocortical (TC) neuron-specific phospholipase C beta 4 (PLC beta 4) knockout (KO) increased the total duration of NREM sleep, consisting of destabilized light NREM and stabilized deep NREM. Surprisingly, the longer NREM sleep did not improve memory consolidation but rather impaired it in TC-specific PLC beta 4 KO mice. Memory function was positively correlated with the stability of light NREM and spindle activity occurring in maintained light NREM period. Our study suggests that a single molecule, PLC beta 4, in TC neurons is critical for tuning the NREM sleep states and thus affects sleep-dependent memory formation. -
dc.identifier.bibliographicCitation SCIENTIFIC REPORTS, v.10, no.1, pp.8813 -
dc.identifier.doi 10.1038/s41598-020-64377-7 -
dc.identifier.issn 2045-2322 -
dc.identifier.scopusid 2-s2.0-85085854756 -
dc.identifier.uri -
dc.identifier.url -
dc.identifier.wosid 000540482200005 -
dc.language 영어 -
dc.title Destabilization of light NREM sleep by thalamic PLC beta 4 deletion impairs sleep-dependent memory consolidation -
dc.type Article -
dc.description.isOpenAccess TRUE -
dc.relation.journalWebOfScienceCategory Multidisciplinary Sciences -
dc.relation.journalResearchArea Science & Technology - Other Topics -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus SPINDLES -
dc.subject.keywordPlus OSCILLATION -
dc.subject.keywordPlus MECHANISMS -
dc.subject.keywordPlus THRESHOLD -
dc.subject.keywordPlus DYNAMICS -
dc.subject.keywordPlus ABSENCE -
dc.subject.keywordPlus HUMANS -
dc.subject.keywordPlus POWER -


Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.