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Grzybowski, Bartosz A.
School of Natural Science
Research Interests
  • Nano science
  • Nanomaterials
  • Programmable Reactions
  • Chemical Networks
  • Cellular Dynamics

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Synthetic connectivity, emergence, and self-regeneration in the network of prebiotic chemistry

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Title
Synthetic connectivity, emergence, and self-regeneration in the network of prebiotic chemistry
Author
Wolos, AgnieszkaRoszak, RafalZadlo-Dobrowolska, AnnaBeker, WiktorMikulak-Klucznik, BarbaraSpolnik, GrzegorzDygas, MiroslawSzymkuc, SaraGrzybowski, Bartosz A.
Issue Date
2020-09
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Citation
SCIENCE, v.369, no.6511, pp.1584
Abstract
The challenge of prebiotic chemistry is to trace the syntheses of life's key building blocks from a handful of primordial substrates. Here we report a forward-synthesis algorithm that generates a full network of prebiotic chemical reactions accessible from these substrates under generally accepted conditions. This network contains both reported and previously unidentified routes to biotic targets, as well as plausible syntheses of abiotic molecules. It also exhibits three forms of nontrivial chemical emergence, as the molecules within the network can act as catalysts of downstream reaction types; form functional chemical systems, including self-regenerating cycles; and produce surfactants relevant to primitive forms of biological compartmentalization. To support these claims, computer-predicted, prebiotic syntheses of several biotic molecules as well as a multistep, self-regenerative cycle of iminodiacetic acid were validated by experiment.
URI
https://scholarworks.unist.ac.kr/handle/201301/49513
URL
https://science.sciencemag.org/content/369/6511/eaaw1955
DOI
10.1126/science.aaw1955
ISSN
0036-8075
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CHM_Journal Papers
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