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Grzybowski, Bartosz A.
School of Natural Science
Research Interests
  • Nano science
  • Nanomaterials
  • Programmable Reactions
  • Chemical Networks
  • Cellular Dynamics


Computational planning of the synthesis of complex natural products

DC Field Value Language Mikulak-Klucznik, Barbara ko Golebiowska, Patrycja ko Bayly, Alison A. ko Popik, Oskar ko Klucznik, Tomasz ko Szymkuc, Sara ko Gajewska, Ewa P. ko Dittwald, Piotr ko Staszewska-Krajewska, Olga ko Beker, Wiktor ko Badowski, Tomasz ko Scheidt, Karl A. ko Molga, Karol ko Mlynarski, Jacek ko Mrksich, Milan ko Grzybowski, Bartosz A. ko 2020-12-31T00:26:44Z - 2020-12-16 ko 2020-12 ko
dc.identifier.citation NATURE, v.588, no.7836, pp.83 - 88 ko
dc.identifier.issn 0028-0836 ko
dc.identifier.uri -
dc.description.abstract Training algorithms to computationally plan multistep organic syntheses has been a challenge for more than 50 years(1-7). However, the field has progressed greatly since the development of early programs such as LHASA(1,7), for which reaction choices at each step were made by human operators. Multiple software platforms(6,8-14) are now capable of completely autonomous planning. But these programs 'think' only one step at a time and have so far been limited to relatively simple targets, the syntheses of which could arguably be designed by human chemists within minutes, without the help of a computer. Furthermore, no algorithm has yet been able to design plausible routes to complex natural products, for which much more far-sighted, multistep planning is necessary(15,16) and closely related literature precedents cannot be relied on. Here we demonstrate that such computational synthesis planning is possible, provided that the program's knowledge of organic chemistry and data-based artificial intelligence routines are augmented with causal relationships(17,18), allowing it to 'strategize' over multiple synthetic steps. Using a Turing-like test administered to synthesis experts, we show that the routes designed by such a program are largely indistinguishable from those designed by humans. We also successfully validated three computer-designed syntheses of natural products in the laboratory. Taken together, these results indicate that expert-level automated synthetic planning is feasible, pending continued improvements to the reaction knowledge base and further code optimization. A synthetic route-planning algorithm, augmented with causal relationships that allow it to strategize over multiple steps, can design complex natural-product syntheses that are indistinguishable from those designed by human experts. ko
dc.language 영어 ko
dc.publisher NATURE RESEARCH ko
dc.title Computational planning of the synthesis of complex natural products ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85092530657 ko
dc.identifier.wosid 000592632700001 ko
dc.type.rims ART ko
dc.identifier.doi 10.1038/s41586-020-2855-y ko
dc.identifier.url ko
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