Related Researcher

Author's Photo

Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery


Intra-mitochondrial Disulfide Polymerization Controls Cancer Cell Necroptosis

DC Field Value Language Kim, Sangpil ko Ryu, Ja-Hyoung ko 2020-12-24T00:38:29Z - 2020-12-23 ko 2020-06-07 ko
dc.identifier.citation 125th General Meeting of the Korean Chemical Society ko
dc.identifier.uri -
dc.description.abstract The energy consuming reactions to biological dissipative state are ubiquitous in biological system, and its mimicry is a great challenge in synthetic chemistry. Herein, we developed intra-mitochondrial polymerization strategy for constructing macroscopic structures by ROS-dissipative system. For the first time, we found that disulfide polymerization is occurred inside cancer mitochondria owing to high ROS concentration of cancer mitochondria, while the disulfide polymerization is hardly happened inside cell due to intracellularly reductive environment. Polymerization process of thiol-containing monomer increases ROS inside mitochondria, which enable the autocatalytic process to accelerate further polymerization and induce mitochondrial dysfunction. This in-situ polymerization shows great potential for anticancer treatment against various cancer cell lines including drug resistant cancer cell. ko
dc.publisher Korean Chemical Society ko
dc.title Intra-mitochondrial Disulfide Polymerization Controls Cancer Cell Necroptosis ko
dc.type CONFERENCE ko
dc.type.rims CONF ko
Appears in Collections:
CHM_Conference Papers

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show simple item record


  • mendeley


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.