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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Therapeutic protein & drug co-loaded biodegradable silica nanoparticle for synergistic anticancer therapy

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dc.contributor.author Choi, Eun Seong ko
dc.contributor.author Ryu, Ja-Hyoung ko
dc.date.available 2020-12-24T00:38:27Z -
dc.date.created 2020-12-23 ko
dc.date.issued 2020-06-07 ko
dc.identifier.citation 125th General Meeting of the Korean Chemical Society ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/49082 -
dc.description.abstract Intracellular protein delivery has an important role, affecting reprogramming of the cell behavior. Despite of advantages of protein delivery, it is hard to deliver proteins due to low permeability and poor stability. Herein, we designed protein and anticancer drug co-loaded biodegradable silica nanoparticle via in-situ reaction. Cytochrome C and Doxorubicin are chosen as therapeutic molecules for anticancer therapy. Biodegradability of silica nanoparticle was controlled by three factors: 1) ratio of TEOS and disulfide precursors, 2) feeding amount of protein and drug, and 3) precursor concentration. Each different silica nanoparticle showed different release profile under 5 mM GSH condition, whether it was stable under deionized water. Further, by the introduction of targeting ligand including poly(ethylene glycol) using Michael-addition chemistry, protein and drug delivery nanosystem may have enhanced stability and selectivity to tumor, leading to apoptosis of cancer cells. ko
dc.publisher Korean Chemical Society ko
dc.title Therapeutic protein & drug co-loaded biodegradable silica nanoparticle for synergistic anticancer therapy ko
dc.type CONFERENCE ko
dc.type.rims CONF ko
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