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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Catalase Conjugated Metal-Organic-Framework for Effective Photodynamic Therapy by Relieving Tumor Hypoxia

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Title
Catalase Conjugated Metal-Organic-Framework for Effective Photodynamic Therapy by Relieving Tumor Hypoxia
Author
Sim, YoujungSeong, JunmoChoi, HuyeonLah, Myoung SooRyu, Ja-Hyoung
Issue Date
2020-06-07
Publisher
Korean Chemical Society
Citation
125th General Meeting of the Korean Chemical Society
Abstract
Photodynamic Therapy (PDT) is a form of a phototherapy inducing cell death using light, oxygen and Photosensitizer (PS) which is generating ROS. These ROS interact with cellular components including lipids, amino acid and nucleic acids, and lead to the cell dysfunction. However, as a tumor grows, it rapidly outgrows its blood supply, leaving portions of the tumor where the oxygen concentration is significantly lower than in healthy tissues. For this reason, even effective photosensitizers cannot be working efficiently as much as expected. Therefore, if we overcome this hypoxia environment of tumor, photodynamic therapy can be more effective way forward. In our research, we conjugate the enzyme catalase (CAT) to surface of biocompatible nanocarrier MOF808. Catalase catalyzes the decomposition of hydrogen peroxide (H2O2) to water (H2O) and oxygen (O2). The generated oxygen can relieve the Hypoxia condition in tumor. Enriched oxygen further increases the PDT effect, enabling effective ROS generation. Also, immobilized enzyme is more stable than the free form of the enzyme enhancing the recyclability of enzymes and minimizing enzyme contamination.
URI
https://scholarworks.unist.ac.kr/handle/201301/49076
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