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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Intramitochondrial Polymerization-induced Self-Assembly (Mito-PISA) Using Covalent Bond Controls Cancer Cell Necrosis

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Title
Intramitochondrial Polymerization-induced Self-Assembly (Mito-PISA) Using Covalent Bond Controls Cancer Cell Necrosis
Author
Kim, SangpilRyu, Ja-Hyoung
Issue Date
2020-10-08
Publisher
The polymer society of Korea
Citation
The 2020 Annual Fall Meeting of Polymer Society of Korea
Abstract
The energy consuming reactions to biological dissipative state are ubiquitous in biological system, and its mimicry is a great challenge in synthetic chemistry. Herein, we developed an intra-mitochondrial polymerization strategy for constructing macroscopic structures by ROS-dissipative system. For the first time, we found that the disulfide polymerization occurred inside cancer mitochondria owing to the high ROS concentration of cancer mitochondria, while it is hardly happened inside cell due to intracellular reductive environment. Polymerization process of thiol-containing monomer further increases ROS level inside mitochondria, which enables the autocatalytic process to accelerate polymerization and induce mitochondrial dysfunction. This in-situ polymerization shows great potential for anticancer treatment against various cancer cell lines including drug resistant cancer cell.
URI
https://scholarworks.unist.ac.kr/handle/201301/49071
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CHM_Conference Papers
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