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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Sequestering ATP Inside Mitochondria by Nucleopeptide Induces Cancer Cell Apoptosis

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Title
Sequestering ATP Inside Mitochondria by Nucleopeptide Induces Cancer Cell Apoptosis
Author
Choi, HuyoenRyu, Ja-Hyoung
Issue Date
2020-10-08
Publisher
The polymer society of Korea
Citation
The 2020 Annual Fall Meeting of Polymer Society of Korea
Abstract
Mitochondria are essential organelles involving in cellular processes, especially adenosine triphosphate (ATP) production. ATP is a major energy source and can be a good eliminating target for anticancer therapy. We describe selective cancer treatment by sequestration of ATP and self-assemblies with ATP inside mitochondria using mitochondria-targeting nucleopeptide (MNP). We designed thymine containing MNP which can interact with ATP through electrostatic interaction and hydrogen bond between MNP and ATP. MNP exhibits selective higher binding affinity with ATP resulting in large complex and assemblies with ATP. MNP preferentially forms large assemblies with ATP even though MNP/ADP (adenosine diphosphate) complex is preformed after addition of ATP. Thus, sequestration of ATP and large assemblies of MNP/ATP inside mitochondria cause physical stress by large structures resulting in apoptosis.
URI
https://scholarworks.unist.ac.kr/handle/201301/49070
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