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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Cloaking Protein Shield Zr-MOF Delivery Platform for Targeted Nanomedicine

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dc.contributor.author Oh, Jun Yong ko
dc.contributor.author Ryu, Ja-Hyoung ko
dc.date.available 2020-12-24T00:38:16Z -
dc.date.created 2020-12-23 ko
dc.date.issued 2020-10-08 ko
dc.identifier.citation The 2020 Annual Fall Meeting of Polymer Society of Korea ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/49069 -
dc.description.abstract In this study, we intended to advance the possibilities of a Zr-MOF-based delivery platform by utilizing self-assembling bonds between the MOF active site and various carboxyl groups in functional shield proteins. Functional cloaking proteins such as GST-Afb (HER2 and EGFR) are very stable, inhibit reactions with other proteins and can be used for targeting. Such proteins can stabilize the active site of the MOF and also act as a targeting moiety. We effectively controlled the MOF surface via an intrinsic reaction between the active site and recombinant proteins to develop a targeted drug delivery platform. This study provides an insight into the potential applications of Zr-MOFs in nanomedicine and the future of the biointerface of MOFs. ko
dc.publisher The polymer society of Korea ko
dc.title Cloaking Protein Shield Zr-MOF Delivery Platform for Targeted Nanomedicine ko
dc.type CONFERENCE ko
dc.type.rims CONF ko
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