BROWSE

Related Researcher

Author's Photo

Min, Seung Kyu
Theoretical/Computational Chemistry Group for Excited State Phenomena
Research Interests
  • Excited state dynamics, photosynthesis, solarcell, light-driven molecular machine

ITEM VIEW & DOWNLOAD

Self‐Assembly of Mitochondria‐Targeted Photosensitizer to Increase Photostability and Photodynamic Therapeutic Efficacy in Hypoxia

DC Field Value Language
dc.contributor.author Jana, Batakrishna ko
dc.contributor.author Thomas, Ajesh P. ko
dc.contributor.author Kim, Sangpil ko
dc.contributor.author Lee, In Seong ko
dc.contributor.author Choi, Huyeon ko
dc.contributor.author Jin, Seongeon ko
dc.contributor.author Park, Soo Ah ko
dc.contributor.author Min, Seung Kyu ko
dc.contributor.author Kim, Chaekyu ko
dc.contributor.author Ryu, Ja-Hyoung ko
dc.date.available 2020-12-24T00:37:25Z -
dc.date.created 2020-12-22 ko
dc.date.issued 2020-08 ko
dc.identifier.citation CHEMISTRY-A EUROPEAN JOURNAL, v.26, no.47, pp.10695 - 10701 ko
dc.identifier.issn 0947-6539 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/49037 -
dc.description.abstract The development of photosensitizers for cancer photodynamic therapy has been challenging due to their low photostability and therapeutic inefficacy in hypoxic tumor microenvironments. To overcome these issues, we have developed a mitochondria-targeted photosensitizer consisting of an indocyanine moiety with triphenylphosphonium arms, which can self-assemble into spherical micelles directed to mitochondria. Self-assembly of the photosensitizer resulted in a higher photostability by preventing free rotation of the indoline ring of the indocyanine moiety. The mitochondria targeting capability of the photosensitizer allowed it to utilize intramitochondrial oxygen. We found that the mitochondria-targeted photosensitizer localized to mitochondria and induced apoptosis of cancer cells both normoxic and hypoxic conditions through generation of ROS. The micellar self-assemblies of the photosensitizer were further confirmed to selectively localize to tumor tissues in a xenograft tumor mouse model through passive targeting and showed efficient tumor growth inhibition. ko
dc.language 영어 ko
dc.publisher John Wiley & Sons Ltd. ko
dc.title Self‐Assembly of Mitochondria‐Targeted Photosensitizer to Increase Photostability and Photodynamic Therapeutic Efficacy in Hypoxia ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85088386158 ko
dc.identifier.wosid 000551456600001 ko
dc.type.rims ART ko
dc.identifier.doi 10.1002/chem.202001366 ko
dc.identifier.url https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202001366 ko
Appears in Collections:
CHM_Journal Papers

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show simple item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU