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Min, Seung Kyu
Theoretical/Computational Chemistry Group for Excited State Phenomena
Research Interests
  • Excited state dynamics, photosynthesis, solarcell, light-driven molecular machine

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Self‐Assembly of Mitochondria‐Targeted Photosensitizer to Increase Photostability and Photodynamic Therapeutic Efficacy in Hypoxia

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Title
Self‐Assembly of Mitochondria‐Targeted Photosensitizer to Increase Photostability and Photodynamic Therapeutic Efficacy in Hypoxia
Author
Jana, BatakrishnaThomas, Ajesh P.Kim, SangpilLee, In SeongChoi, HuyeonJin, SeongeonPark, Soo AhMin, Seung KyuKim, ChaekyuRyu, Ja-Hyoung
Issue Date
2020-08
Publisher
John Wiley & Sons Ltd.
Citation
CHEMISTRY-A EUROPEAN JOURNAL, v.26, no.47, pp.10695 - 10701
Abstract
The development of photosensitizers for cancer photodynamic therapy has been challenging due to their low photostability and therapeutic inefficacy in hypoxic tumor microenvironments. To overcome these issues, we have developed a mitochondria-targeted photosensitizer consisting of an indocyanine moiety with triphenylphosphonium arms, which can self-assemble into spherical micelles directed to mitochondria. Self-assembly of the photosensitizer resulted in a higher photostability by preventing free rotation of the indoline ring of the indocyanine moiety. The mitochondria targeting capability of the photosensitizer allowed it to utilize intramitochondrial oxygen. We found that the mitochondria-targeted photosensitizer localized to mitochondria and induced apoptosis of cancer cells both normoxic and hypoxic conditions through generation of ROS. The micellar self-assemblies of the photosensitizer were further confirmed to selectively localize to tumor tissues in a xenograft tumor mouse model through passive targeting and showed efficient tumor growth inhibition.
URI
https://scholarworks.unist.ac.kr/handle/201301/49037
URL
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202001366
DOI
10.1002/chem.202001366
ISSN
0947-6539
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CHM_Journal Papers
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