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Cho, Yoon-Kyoung
Integrated Nano-Biotech Lab (INBL)
Research Interests
  • Microfluidics, Lab-on-a-chip, personalized biomedical diagnostics, nanobioengineering

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Circulating Tumor Cells and TWIST Expression in Patients with Metastatic Gastric Cancer

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Title
Circulating Tumor Cells and TWIST Expression in Patients with Metastatic Gastric Cancer
Author
Jhi, Joon HyungKim, Gwang HaPark, Su JinKim, Dong UkLee, Moon WonLee, Bong EunKwon, Chae HwaCho, Yoon-Kyoung
Issue Date
2020-11
Publisher
BioMed Central
Citation
BMC GASTROENTEROLOGY
Abstract
Background: The clinical significance of circulating tumor cells (CTCs) and TWIST expression in CTCs remains unelucidated in patients with gastric cancer (GC). Here, we evaluated CTCs and TWIST expression in CTCs and explored their correlation with prognosis in patients with metastatic GC. Methods: Peripheral blood samples were prospectively obtained from 31 patients with metastatic GC between September 2017 and December 2018, prior to treatment. CTCs were detected using a centrifugal microfluidic system and CTCs positive for TWIST immunostaining were defined as TWIST (+) CTCs. CTCs and TWIST (+) Results: CTCs were detected in 25 (80.6%) of the 31 patients. CTC count in patients with first diagnosis of metastatic cancer tended to be higher than that in those with recurrent metastatic cancer, but TWIST (+) CTC count was not different between the two groups. There was no difference in CTC and TWIST (+) CTC counts according to histopathologic type, peritoneal dissemination, hematogenous metastasis, serum tumor makers, or response to first-line chemotherapy. Patients with CTCs >7.5/7.5 mL of blood showed shorter overall survival (OS) than those with CTCs ≤7.5/7.5 mL of blood (P = 0.049). Additionally, patients with TWIST (+) CTCs >2.5/7.5 mL of blood showed shorter OS than those with TWIST (+) CTCs ≤2.5/7.5 mL of blood (P = 0.105). Conclusions: Our study demonstrated that high levels of CTCs and TWIST (+) CTCs were associated with worse OS.
URI
https://scholarworks.unist.ac.kr/handle/201301/48833
URL
https://www.researchsquare.com/article/rs-102500/v1
DOI
10.21203/rs.3.rs-102500/v1
ISSN
1471-230X
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BME_Journal Papers
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