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Choi, Sung-Deuk
Environmental Analytical Chemistry Lab (EACL)
Research Interests
  • Persistent organic pollutants, Environmental Analysis and monitoring, Multimedia modeling, Fine particle

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Acute toxicities of fluorene, fluorene-1-carboxylic acid, and fluorene-9-carboxylic acid on zebrafish embryos (Danio rerio): Molecular mechanisms of developmental toxicities of fluorene-1-carboxylic acid

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dc.contributor.author Kim, Yong-Chan ko
dc.contributor.author Lee, Sang-Ryong ko
dc.contributor.author Jeon, Hwang-Ju ko
dc.contributor.author Kim, Kyeongnam ko
dc.contributor.author Kim, Myoung-Jin ko
dc.contributor.author Choi, Sung-Deuk ko
dc.contributor.author Lee, Sung-Eun ko
dc.date.available 2020-10-30T00:31:31Z -
dc.date.created 2020-10-23 ko
dc.date.issued 2020-12 ko
dc.identifier.citation CHEMOSPHERE, v.260, pp.127622 ko
dc.identifier.issn 0045-6535 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/48569 -
dc.description.abstract In this study, fluorene (FL), FL-1-carboxylic acid (FC-1), and FL-9-carboxylic acid (FC-9) were investigated to understand their acute toxicity by measuring inhibitory effects on hatching rates and developmental processes of zebrafish embryos (Danio rerio). For exposure concentrations up to 3000 mu g/L, FC-1 alone showed acute toxicity at 1458 ng/L for LC50 value. FC-1 caused yolk sac and spinal deformities, and pericardial edema. Molecular studies were undertaken to understand FC-1 toxicity examining 61 genes after exposure to 5 mu M (equivalent to LC20 value of FC-1) in embryos. In the FC-1-treated embryos, the expression of the cyp7a1 gene, involved in bile acid biosynthesis, was dramatically decreased, while the expression of the Il-1 beta gene involved in inflammation was remarkably increased. In addition to these findings, in FC-1-treated embryos, the expression of nppa gene related to the differentiation of the myocardium was 3-fold increased. On the other hand, cyp1a, cyp3a, ugt1a1, abcc4, mdr1, and sult1st1 responsible for detoxification of xenobiotics were upregulated in FC-9-treated embryos. Taken together, carboxylation on carbon 1 of FL increased acute toxicity in zebrafish embryos, and its toxicity might be related to morphological changes with modification of normal biological functions and lowered defense ability. (C) 2020 Elsevier Ltd. All rights reserved. ko
dc.language 영어 ko
dc.publisher PERGAMON-ELSEVIER SCIENCE LTD ko
dc.title Acute toxicities of fluorene, fluorene-1-carboxylic acid, and fluorene-9-carboxylic acid on zebrafish embryos (Danio rerio): Molecular mechanisms of developmental toxicities of fluorene-1-carboxylic acid ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85087758640 ko
dc.identifier.wosid 000575197000090 ko
dc.type.rims ART ko
dc.identifier.doi 10.1016/j.chemosphere.2020.127622 ko
dc.identifier.url https://www.sciencedirect.com/science/article/pii/S0045653520318178?via%3Dihub ko
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