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DC Field | Value | Language |
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dc.citation.number | 17 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 21 | - |
dc.contributor.author | Kim, Dong Jin | - |
dc.contributor.author | Jeena, M. T. | - |
dc.contributor.author | Kim, Ok-Hee | - |
dc.contributor.author | Hong, Ha-Eun | - |
dc.contributor.author | Seo, Haeyeon | - |
dc.contributor.author | Ryu, Ja-Hyoung | - |
dc.contributor.author | Kim, Say-June | - |
dc.date.accessioned | 2023-12-21T17:07:16Z | - |
dc.date.available | 2023-12-21T17:07:16Z | - |
dc.date.created | 2020-10-07 | - |
dc.date.issued | 2020-09 | - |
dc.description.abstract | Here, we provide the possibility of a novel chemotherapeutic agent against gastric cancer cells, comprising the combination of 5-fluorouracil (5-FU) and a mitochondria-targeting self-assembly peptide, which is a phenylalanine dipeptide with triphenyl phosphonium (Mito-FF). The anticancer effects and mechanisms of 5-FU and Mito-FF, individually or in combination, were compared through both in vitro and in vivo models of gastric cancer. Our experiments consistently demonstrated that the 5-FU and Mito-FF combination therapy was superior to monotherapy with either, as manifested by both higher reduction of proliferation as well as an induction of apoptotic cell death. Interestingly, we found that combining 5-FU with Mito-FF leads to a significant increase of reactive oxygen species (ROS) and reduction of antioxidant enzymes in gastric cancer cells. Moreover, the inhibition of ROS abrogated the pro-apoptotic effects of combination therapy, suggesting that enhanced oxidative stress could be the principal mechanism of the action of combination therapy. We conclude that the combination of 5-FU and Mito-FF exerts potent antineoplastic activity against gastric cancer cells, primarily by promoting ROS generation and suppressing the activities of antioxidant enzymes. | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.21, no.17 | - |
dc.identifier.doi | 10.3390/ijms21176126 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.scopusid | 2-s2.0-85090018996 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/48315 | - |
dc.identifier.url | https://www.mdpi.com/1422-0067/21/17/6126 | - |
dc.identifier.wosid | 000570370700001 | - |
dc.language | 영어 | - |
dc.publisher | MDPI | - |
dc.title | Novel Therapeutic Application of Self-Assembly Peptides Targeting the Mitochondria in In Vitro and In Vivo Experimental Models of Gastric Cancer | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Chemistry | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Mito-FF (mitochondria-accumulating phenylalanine dipeptide with triphenyl phosphonium) | - |
dc.subject.keywordAuthor | 5-fluorouracil | - |
dc.subject.keywordAuthor | self-assembly | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordAuthor | antioxidant enzymes | - |
dc.subject.keywordPlus | MECHANISMS | - |
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