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Cho, Yoon-Kyoung
Integrated Nano-Biotech Lab (INBL)
Research Interests
  • Microfluidics, Lab-on-a-chip, personalized biomedical diagnostics, nanobioengineering

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Detection of EGFR Mutations Using Bronchial Washing-Derived Extracellular Vesicles in Patients with Non-Small-Cell Lung Carcinoma

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dc.contributor.author Park, Juhee ko
dc.contributor.author Lee, Chaeeun ko
dc.contributor.author Eom, Jung Seop ko
dc.contributor.author Kim, Mi-Hyun ko
dc.contributor.author Cho, Yoon-Kyoung ko
dc.date.available 2020-10-22T08:08:51Z -
dc.date.created 2020-10-13 ko
dc.date.issued 2020-09 ko
dc.identifier.citation CANCERS, v.12, no.10, pp.2822 ko
dc.identifier.issn 2072-6694 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/48292 -
dc.description.abstract The detection of epidermal growth factor receptor (EGFR) mutation, based on tissue biopsy samples, provides a valuable guideline for the prognosis and precision medicine in patients with lung cancer. In this study, we aimed to examine minimally invasive bronchial washing (BW)-derived extracellular vesicles (EVs) for EGFR mutation analysis in patients with lung cancer. A lab-on-a-disc equipped with a filter with 20-nm pore diameter, Exo-Disc, was used to enrich EVs in BW samples. The overall detection sensitivity of EGFR mutations in 55 BW-derived samples was 89.7% and 31.0% for EV-derived DNA (EV-DNA) and EV-excluded cell free-DNA (EV-X-cfDNA), respectively, with 100% specificity. The detection rate of T790M in 13 matched samples was 61.5%, 10.0%, and 30.8% from BW-derived EV-DNA, plasma-derived cfDNA, and tissue samples, respectively. The acquisition of T790M resistance mutation was detected earlier in BW-derived EVs than plasma or tissue samples. The longitudinal analysis of BW-derived EVs showed excellent correlation with the disease progression measured by CT images. The EGFR mutations can be readily detected in BW-derived EVs, which demonstrates their clinical potential as a liquid-biopsy sample that may aid precise management, including assessment of the treatment response and drug resistance in patients with lung cancer. ko
dc.language 영어 ko
dc.publisher Multidisciplinary Digital Publishing Institute (MDPI) ko
dc.title Detection of EGFR Mutations Using Bronchial Washing-Derived Extracellular Vesicles in Patients with Non-Small-Cell Lung Carcinoma ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85091837575 ko
dc.identifier.wosid 000582657600001 ko
dc.type.rims ART ko
dc.identifier.doi 10.3390/cancers12102822 ko
dc.identifier.url https://www.mdpi.com/2072-6694/12/10/2822 ko
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