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Amblard, Francois
Statistical physics, optics and cells
Research Interests
  • Cell mechanics, cytoskeleton dynamics in/stability, cell adhesion.
  • Optical control of gene expression and oncogenic switches, sociology of the epithelial-to-mesenchymal transition.
  • Nonlinear optical imaging, optics and detection of thermal radiation.
  • Nanoscale heat transfer, water metastability and microscopic vapor explosions.
  • Ultraweak chemi-luminescence of the oxidative stress and of oxidation reactions.
  • Diffusive wave spectroscopy & cavity-amplified light scattering of protein activity & liquids.
  • 3D random optical interferometry: instrumentation, experiments & applications.
  • Theory of coherent photon gases, 3D random interferometry, stochastic dielectric spectroscopy, electromagnetism with random tensors.


Adaptive architecture and mechanoresponse of epithelial cells on a torus

DC Field Value Language Yu, S-M. ko Li, B. ko Amblard, Francois ko Granick, Steve ko Cho, Yoon-Kyoung ko 2020-10-22T08:08:18Z - 2020-10-13 ko 2021-01 ko
dc.identifier.citation BIOMATERIALS, v.265, pp.120420 ko
dc.identifier.issn 0142-9612 ko
dc.identifier.uri -
dc.description.abstract Curvature is a geometric feature widely observed in the epithelia and critical to the performance of fundamental biological functions. Understanding curvature-related biophysical phenomena remains challenging partly owing to the difficulty of quantitatively tuning and measuring curvatures of interfacing individual cells. In this study, we prepared confluent wild-type Madin-Darby canine kidney cells on a torus structure presenting positive, zero, and negative Gaussian curvatures with a tubule diameter of 2-7 cells and quantified the mechanobiological characteristics of individual cells. Cells on the torus surface exhibited topological sensing ability both as an individual cell and collective cell organization. Both cell bodies and nuclei, adapted on the torus, exhibited local Gaussian curvature-dependent preferential orientation. The cells on the torus demonstrated significant adjustment in the nuclear area and exhibited asymmetric nuclear position depending on the local Gaussian curvature. Moreover, cells on top of the torus, where local Gaussian curvature is near zero, exhibited more sensitive morphological adaptations than the nuclei depending on the Gaussian curvature gradient. Furthermore, the spatial heterogeneity of intermediate filament proteins related to mechanoresponsive expression of the cell body and nucleus, vimentin, keratin and lamin A, revealed local Gaussian curvature as a key factor of cellular adaptation on curved surfaces. ko
dc.language 영어 ko
dc.publisher ELSEVIER SCI LTD ko
dc.title Adaptive architecture and mechanoresponse of epithelial cells on a torus ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85091641946 ko
dc.identifier.wosid 000591609000003 ko
dc.type.rims ART ko
dc.identifier.doi 10.1016/j.biomaterials.2020.120420 ko
dc.identifier.url ko
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