Full metadata record
DC Field | Value | Language |
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dc.citation.number | 14 | - |
dc.citation.startPage | 5080 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 21 | - |
dc.contributor.author | Jeong, Munki | - |
dc.contributor.author | Jung, Euitaek | - |
dc.contributor.author | Lee, Young Han | - |
dc.contributor.author | Seo, Jeong Kon | - |
dc.contributor.author | Ahn, Seunghyun | - |
dc.contributor.author | Koh, Dongsoo | - |
dc.contributor.author | Lim, Yoongho | - |
dc.contributor.author | Shin, Soon Young | - |
dc.date.accessioned | 2023-12-21T17:13:53Z | - |
dc.date.available | 2023-12-21T17:13:53Z | - |
dc.date.created | 2020-09-03 | - |
dc.date.issued | 2020-07 | - |
dc.description.abstract | Breast cancer is a common malignancy among women worldwide. Gelatinases such as matrix metallopeptidase 2 (MMP2) and MMP9 play crucial roles in cancer cell migration, invasion, and metastasis. To develop a novel platform compound, we synthesized a flavonoid derivative, (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile (named DK4023) and characterized its inhibitory effects on the motility andMMP2andMMP9expression of highly metastatic MDA-MB-231 breast cancer cells. We found that DK4023 inhibited tumor necrosis factor alpha (TNF alpha)-induced motility and F-actin formation of MDA-MB-231 cells. DK4023 also suppressed the TNF alpha-induced mRNA expression ofMMP9through the downregulation of the TNF alpha-extracellular signal-regulated kinase (ERK)/early growth response 1 (EGR-1) signaling axis. These results suggest that DK4023 could serve as a potential platform compound for the development of novel chemopreventive/chemotherapeutic agents against invasive breast cancer. | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.21, no.14, pp.5080 | - |
dc.identifier.doi | 10.3390/ijms21145080 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.scopusid | 2-s2.0-85088413142 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/48083 | - |
dc.identifier.url | https://www.mdpi.com/1422-0067/21/14/5080 | - |
dc.identifier.wosid | 000557688900001 | - |
dc.language | 영어 | - |
dc.publisher | MDPI | - |
dc.title | A Novel Synthetic Compound (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile Inhibits TNF alpha-Induced MMP9 Expression via EGR-1 Downregulation in MDA-MB-231 Human Breast Cancer Cells | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Chemistry | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | EGR-1 | - |
dc.subject.keywordAuthor | flavonoid | - |
dc.subject.keywordAuthor | (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile | - |
dc.subject.keywordAuthor | MDA-MB-231 | - |
dc.subject.keywordAuthor | MMP9 | - |
dc.subject.keywordAuthor | TNF alpha | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | SUPPRESSOR | - |
dc.subject.keywordPlus | GENE | - |
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