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DC Field | Value | Language |
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dc.citation.endPage | 9021 | - |
dc.citation.number | 33 | - |
dc.citation.startPage | 9017 | - |
dc.citation.title | CHEMICAL SCIENCE | - |
dc.citation.volume | 11 | - |
dc.contributor.author | Kwon, Nam | - |
dc.contributor.author | Suh, Jong-Min | - |
dc.contributor.author | Lim, Mi Hee | - |
dc.contributor.author | Hirao, Hajime | - |
dc.contributor.author | Cho, Jaeheung | - |
dc.date.accessioned | 2023-12-21T17:10:05Z | - |
dc.date.available | 2023-12-21T17:10:05Z | - |
dc.date.created | 2020-09-03 | - |
dc.date.issued | 2020-08 | - |
dc.description.abstract | A hydroxamate transfer reaction between metal complexes has been investigated by a combination of experimental and theoretical studies. A hydroxamate-bound cobalt(II) complex bearing a tetradentate macrocyclic ligand, [CoII(TBDAP)(CH3C(–NHO)O)]+ (1), is prepared by the reduction of a hydroximatocobalt(III) complex with a biological reductant. Alternatively, 1 is accessible via a synthetic route for the reaction between the cobalt(II) complex and acetohydroxamic acid in the presence of a base. 1 was isolated and characterized by various physicochemical methods, including UV-vis, IR, ESI-MS, and X-ray crystallography. The hydroxamate transfer reactivity of 1 was examined with a zinc complex, which was followed by UV-vis and ESI-MS. Kinetic and activation parameter data suggest that the hydroxamate transfer reaction occurs via a bimolecular mechanism, which is also supported by DFT calculations. Moreover, 1 is able to inhibit the activity against a zinc enzyme, i.e., matrix metalloproteinase-9. Our overall investigations of the hydroxamate transfer using the synthetic model system provide considerable insight into the final step involved in the inhibition of zinc-containing enzymes. | - |
dc.identifier.bibliographicCitation | CHEMICAL SCIENCE, v.11, no.33, pp.9017 - 9021 | - |
dc.identifier.doi | 10.1039/d0sc02676j | - |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/48075 | - |
dc.identifier.url | https://pubs.rsc.org/en/content/articlelanding/2020/sc/d0sc02676j#!divAbstract | - |
dc.identifier.wosid | 000562597500035 | - |
dc.language | 영어 | - |
dc.publisher | Royal Society of Chemistry | - |
dc.title | Mechanistic insight into hydroxamate transfer reaction mimicking the inhibition of zinc-containing enzymes | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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