In this paper, a centralized retransmission management with Software Defined Network (SDN) is proposed in order to handle packet loss in multi-hop wireless access networks. The proposed scheme manages retransmission persistence for Automatic Repeat Request (ARQ) in all wireless links, which satisfies a delay constraint and maintains end-to-end throughput. Simulation results show that the proposed scheme allows both throughput improvement and less average delay than a delay constraint by adjusting the trade-off between throughput and wireless delay.