There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 8348 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 8342 | - |
dc.citation.title | ANALYTICAL CHEMISTRY | - |
dc.citation.volume | 82 | - |
dc.contributor.author | Park, Jin-Young | - |
dc.contributor.author | Lee, Yoon-suk | - |
dc.contributor.author | Chang, Byoung-Yong | - |
dc.contributor.author | Kim, Byeang Hyean | - |
dc.contributor.author | Jeon, Sangmin | - |
dc.contributor.author | Park, Su-Moon | - |
dc.date.accessioned | 2023-12-22T06:43:18Z | - |
dc.date.available | 2023-12-22T06:43:18Z | - |
dc.date.created | 2013-06-20 | - |
dc.date.issued | 2010-10 | - |
dc.description.abstract | A ribonucleic acid (RNA) sensor based on hybridization of its peptide nucleic acid (PNA) molecule with a target RNA oligomer of the internal ribosome entry site sequence specific to the hepatitis C virus (HCV) and the electrochemical impedance detection is described. This RNA is one of the most conservative molecules of the whole HCV RNA genome. The ammonium ion terminated PNA molecule was immobilized via its host-guest interactions with the diaza crown ring of 3-thiophene-acetamide-diaza-18-crown-6 synthesized by a simple two-step method, which forms a well-defined self-assembled monolayer (SAM) on gold. Hybridization events of the probe PNA with the target RNA were monitored by measuring charge-transfer resistances for the Fe(CN)(6)(3-/4-) redox probe using Fourier transform electrochemical impedance spectroscopy. The ratio of the resistances of the SAM-covered electrode measured before and after hybridization increased linearly with log[RNA] in the rat liver lysate with a detection limit of about 23 pM. | - |
dc.identifier.bibliographicCitation | ANALYTICAL CHEMISTRY, v.82, no.19, pp.8342 - 8348 | - |
dc.identifier.doi | 10.1021/ac1019232 | - |
dc.identifier.issn | 0003-2700 | - |
dc.identifier.scopusid | 2-s2.0-77957313222 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/4273 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77957313222 | - |
dc.identifier.wosid | 000282257400065 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Label-Free Impedimetric Sensor for a Ribonucleic Acid Oligomer Specific to Hepatitis C Virus at a Self-Assembled Monolayer-Covered Electrode | - |
dc.type | Article | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.