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DC Field | Value | Language |
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dc.citation.endPage | 349 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 340 | - |
dc.citation.title | MOLECULAR IMAGING AND BIOLOGY | - |
dc.citation.volume | 16 | - |
dc.contributor.author | Noh, Gwang Tae | - |
dc.contributor.author | Kim, Mi-Hyun | - |
dc.contributor.author | Suh, Ji-Yeon | - |
dc.contributor.author | Song, Youngkyu | - |
dc.contributor.author | Lee, Chang Kyung | - |
dc.contributor.author | Baek, Jin Hee | - |
dc.contributor.author | Lee, Yong Seok | - |
dc.contributor.author | Cho, Gyunggoo | - |
dc.contributor.author | Kim, Eunju | - |
dc.contributor.author | Kim, Young Ro | - |
dc.contributor.author | Cho, Hyungjoon | - |
dc.contributor.author | Lim, Dongyeol | - |
dc.contributor.author | Kim, Jeong Kon | - |
dc.date.accessioned | 2023-12-22T02:39:34Z | - |
dc.date.available | 2023-12-22T02:39:34Z | - |
dc.date.created | 2013-11-14 | - |
dc.date.issued | 2014-06 | - |
dc.description.abstract | This study was conducted to evaluate feasibility of sunitinib-CLIO conjugate as a vascular endothelial growth factor receptor/platelet-derived growth factor receptor (VEGFR/PDGFR)-specific magnetic resonance (MR) probe. VEGFR/PDGFR-targeting MR probe was synthesized by conjugating cross-linked iron-oxide (CLIO) with tyrosine-kinase inhibitor (sunitinib). In VEGFR/PDGFR-positive (U118MG) and VEGFR/PDGFR-negative (HT29) cells and tumor models, conjugate-driven Delta R (2) was estimated, while CLIO was used as control. Prussian-blue staining was performed for quantifying the amount of tumor-binding conjugates. Delta R (2) between sunitinib-CLIO-treated and non-treated cells was greater in U118MG (mean, 2.1/s) than in HT29 cells (1.0/s). In in vivo study, conjugate induced a greater Delta R (2) in U118MG (11.2/s) than HT29 tumors (5.9/s). Conjugate-induced R (2) changes were not correlated with degree of Gd-DTPA enhancement, demonstrating that tumor binding of sunitinib-CLIO was independent of enhanced permeability and retention effect. % area of Prussian-blue staining was greater in U118MG (8.5 %) than in HT29 (1.4 %). Sunitinib-CLIO conjugate can be used as an active MR probe for quantifying VEGFR/PDGFR. |
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dc.identifier.bibliographicCitation | MOLECULAR IMAGING AND BIOLOGY, v.16, no.3, pp.340 - 349 | - |
dc.identifier.doi | 10.1007/s11307-013-0697-9 | - |
dc.identifier.issn | 1536-1632 | - |
dc.identifier.scopusid | 2-s2.0-84902544698 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/4272 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84902544698 | - |
dc.identifier.wosid | 000335734900006 | - |
dc.language | 영어 | - |
dc.publisher | SPRINGER | - |
dc.title | Sunitinib-CLIO Conjugate: A VEGFR/PDGFR-Targeting Active MR Probe | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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