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Cho, Hyungjoon
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dc.citation.endPage 349 -
dc.citation.number 3 -
dc.citation.startPage 340 -
dc.citation.volume 16 - Noh, Gwang Tae - Kim, Mi-Hyun - Suh, Ji-Yeon - Song, Youngkyu - Lee, Chang Kyung - Baek, Jin Hee - Lee, Yong Seok - Cho, Gyunggoo - Kim, Eunju - Kim, Young Ro - Cho, Hyungjoon - Lim, Dongyeol - Kim, Jeong Kon - 2023-12-22T02:39:34Z - 2023-12-22T02:39:34Z - 2013-11-14 - 2014-06 -
dc.description.abstract This study was conducted to evaluate feasibility of sunitinib-CLIO conjugate as a vascular endothelial growth factor receptor/platelet-derived growth factor receptor (VEGFR/PDGFR)-specific magnetic resonance (MR) probe.

VEGFR/PDGFR-targeting MR probe was synthesized by conjugating cross-linked iron-oxide (CLIO) with tyrosine-kinase inhibitor (sunitinib). In VEGFR/PDGFR-positive (U118MG) and VEGFR/PDGFR-negative (HT29) cells and tumor models, conjugate-driven Delta R (2) was estimated, while CLIO was used as control. Prussian-blue staining was performed for quantifying the amount of tumor-binding conjugates.

Delta R (2) between sunitinib-CLIO-treated and non-treated cells was greater in U118MG (mean, 2.1/s) than in HT29 cells (1.0/s). In in vivo study, conjugate induced a greater Delta R (2) in U118MG (11.2/s) than HT29 tumors (5.9/s). Conjugate-induced R (2) changes were not correlated with degree of Gd-DTPA enhancement, demonstrating that tumor binding of sunitinib-CLIO was independent of enhanced permeability and retention effect. % area of Prussian-blue staining was greater in U118MG (8.5 %) than in HT29 (1.4 %).

Sunitinib-CLIO conjugate can be used as an active MR probe for quantifying VEGFR/PDGFR.
dc.identifier.bibliographicCitation MOLECULAR IMAGING AND BIOLOGY, v.16, no.3, pp.340 - 349 -
dc.identifier.doi 10.1007/s11307-013-0697-9 -
dc.identifier.issn 1536-1632 -
dc.identifier.scopusid 2-s2.0-84902544698 -
dc.identifier.uri -
dc.identifier.url -
dc.identifier.wosid 000335734900006 -
dc.language 영어 -
dc.publisher SPRINGER -
dc.title Sunitinib-CLIO Conjugate: A VEGFR/PDGFR-Targeting Active MR Probe -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Radiology, Nuclear Medicine & Medical Imaging -
dc.relation.journalResearchArea Radiology, Nuclear Medicine & Medical Imaging -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -


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