Fully Integrated Immunoassays on a Disc

Abstract

We report on a fully automated "lab-on-a-disc" system for multiplex immunoassay starting from real samples such as whole blood or saliva. While immunoassay has been a standard tool in identification of protein biomarkers in clinical diagnostics, the tests can be labor intensive and time consuming. Integration with microfluidic technology allows more precise control of fluids while also reducing the expensive reagent consumption, the required analysis time and possible handling errors. In this paper, a lab-on-a-disc for multiplex immunoassay is introduced in addition to the recently reported fully integrated bead-based immunoassay on a disc (1) and simultaneous analysis of biochemistry and immunoassays on a disc (2).