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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 788 | - |
dc.citation.startPage | 780 | - |
dc.citation.title | ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY | - |
dc.citation.volume | 70 | - |
dc.contributor.author | Ahn, Jae-Woo | - |
dc.contributor.author | Kim, Sangwoo | - |
dc.contributor.author | Kim, Eun-Jung | - |
dc.contributor.author | Kim, Yeo-Jin | - |
dc.contributor.author | Kim, Kyung-Jin | - |
dc.date.accessioned | 2023-12-22T02:47:34Z | - |
dc.date.available | 2023-12-22T02:47:34Z | - |
dc.date.created | 2014-04-03 | - |
dc.date.issued | 2014-03 | - |
dc.description.abstract | The hPrp19-CDC5L complex plays a crucial role during human pre-mRNA splicing by catalytic activation of the spliceosome. In order to elucidate the molecular architecture of the hPrp19-CDC5L complex, the crystal structure of CTNNBL1, one of the major components of this complex, was determined. Unlike canonical ARM-repeat proteins such as beta-catenin and importin-alpha, CTNNBL1 was found to contain a twisted and extended ARM-repeat structure at the C-terminal domain and, more importantly, the protein formed a stable dimer. A highly negatively charged patch formed in the N-terminal ARM-repeat domain of CTNNBL1 provides a binding site for CDC5L, a binding partner of the protein in the hPrp19-CDC5L complex, and these two proteins form a complex with a stoichiometry of 2:2. These findings not only present the crystal structure of a novel ARM-repeat protein, CTNNBL1, but also provide insights into the detailed molecular architecture of the hPrp19-CDC5L complex. | - |
dc.identifier.bibliographicCitation | ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, v.70, pp.780 - 788 | - |
dc.identifier.doi | 10.1107/S139900471303318X | - |
dc.identifier.issn | 0907-4449 | - |
dc.identifier.scopusid | 2-s2.0-84896779873 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/4214 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84896779873 | - |
dc.identifier.wosid | 000332406600017 | - |
dc.language | 영어 | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods; Biochemistry & Molecular Biology; Biophysics; Crystallography | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Biophysics; Crystallography | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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