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Hong, Sung You
Synthetic Organic Chemistry Laboratory
Research Interests
  • Synthetic organic chemistry, transition metals, oxidation state

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Ferritin protein cage nanoparticles as versatile antigen delivery nanoplatforms for dendritic cell (DC)-based vaccine development

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dc.contributor.author Han, Jae-A ko
dc.contributor.author Kang, Young Ji ko
dc.contributor.author Shin, Changsik ko
dc.contributor.author Ra, Jae-Sun ko
dc.contributor.author Shin, Hyun-Hee ko
dc.contributor.author Hong, Sung You ko
dc.contributor.author Do, Yoonkyung ko
dc.contributor.author Kang, Sebyung ko
dc.date.available 2014-04-10T02:34:02Z -
dc.date.created 2014-01-03 ko
dc.date.issued 2014-04 ko
dc.identifier.citation NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, v.10, no.3, pp.561 - 569 ko
dc.identifier.issn 1549-9634 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/3964 -
dc.description.abstract We utilized ferritin protein cage nanoparticles (FPCN) as antigen delivery nanoplatforms for DC-based vaccine development and investigated DC-mediated antigen-specific immune responses. Antigenic peptides, OT-1 (SIINFEKL) or OT-2 (ISQAVHAAHAEINEAGR) which are derived from ovalbumin, were genetically introduced either onto the exterior surface or into the interior cavity of FPCN. FPCN carrying antigenic peptides (OT-1-FPCN and OT-2-FPCN) were effectively delivered to DCs and processed within endosomes. Delivered antigenic peptides, OT-1 or OT-2, to DCs successfully induced antigen-specific CD8+ or CD4+ T cell proliferations both in vitro and in vivo. Naïve mice immunized with OT-1-FPCN efficiently differentiated OT-1 specific CD8+ T cells into functional effector cytotoxic T cells resulting in selective killing of antigen-specific target cells. Effective differentiation of proliferated OT-2 specific CD4+ T cells into functional CD4+ Th1 and Th2 cells was confirmed with the productions of IFN-γ/IL-2 and IL-10/IL-13 cytokines, respectively. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher ELSEVIER SCIENCE BV ko
dc.title Ferritin protein cage nanoparticles as versatile antigen delivery nanoplatforms for dendritic cell (DC)-based vaccine development ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84896549424 ko
dc.identifier.wosid 000333812100008 ko
dc.type.rims ART ko
dc.description.wostc 0 *
dc.description.scopustc 0 *
dc.date.tcdate 2014-10-18 *
dc.date.scptcdate 2014-07-12 *
dc.identifier.doi 10.1016/j.nano.2013.11.003 ko
dc.identifier.url https://www.sciencedirect.com/science/article/pii/S1549963413005923?via%3Dihub ko
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CHM_Journal Papers
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