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DC Field | Value | Language |
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dc.citation.endPage | 569 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 561 | - |
dc.citation.title | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | - |
dc.citation.volume | 10 | - |
dc.contributor.author | Han, Jae-A | - |
dc.contributor.author | Kang, Young Ji | - |
dc.contributor.author | Shin, Changsik | - |
dc.contributor.author | Ra, Jae-Sun | - |
dc.contributor.author | Shin, Hyun-Hee | - |
dc.contributor.author | Hong, Sung You | - |
dc.contributor.author | Do, Yoonkyung | - |
dc.contributor.author | Kang, Sebyung | - |
dc.date.accessioned | 2023-12-22T02:45:07Z | - |
dc.date.available | 2023-12-22T02:45:07Z | - |
dc.date.created | 2014-01-03 | - |
dc.date.issued | 2014-04 | - |
dc.description.abstract | We utilized ferritin protein cage nanoparticles (FPCN) as antigen delivery nanoplatforms for DC-based vaccine development and investigated DC-mediated antigen-specific immune responses. Antigenic peptides, OT-1 (SIINFEKL) or OT-2 (ISQAVHAAHAEINEAGR) which are derived from ovalbumin, were genetically introduced either onto the exterior surface or into the interior cavity of FPCN. FPCN carrying antigenic peptides (OT-1-FPCN and OT-2-FPCN) were effectively delivered to DCs and processed within endosomes. Delivered antigenic peptides, OT-1 or OT-2, to DCs successfully induced antigen-specific CD8+ or CD4+ T cell proliferations both in vitro and in vivo. Naïve mice immunized with OT-1-FPCN efficiently differentiated OT-1 specific CD8+ T cells into functional effector cytotoxic T cells resulting in selective killing of antigen-specific target cells. Effective differentiation of proliferated OT-2 specific CD4+ T cells into functional CD4+ Th1 and Th2 cells was confirmed with the productions of IFN-γ/IL-2 and IL-10/IL-13 cytokines, respectively. | - |
dc.identifier.bibliographicCitation | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, v.10, no.3, pp.561 - 569 | - |
dc.identifier.doi | 10.1016/j.nano.2013.11.003 | - |
dc.identifier.issn | 1549-9634 | - |
dc.identifier.scopusid | 2-s2.0-84896549424 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/3964 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1549963413005923?via%3Dihub | - |
dc.identifier.wosid | 000333812100008 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Ferritin protein cage nanoparticles as versatile antigen delivery nanoplatforms for dendritic cell (DC)-based vaccine development | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology; Medicine, Research & Experimental | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics; Research & Experimental Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Ferritin | - |
dc.subject.keywordAuthor | Protein cage | - |
dc.subject.keywordAuthor | Antigen delivery | - |
dc.subject.keywordAuthor | Dendritic cells | - |
dc.subject.keywordAuthor | Vaccine | - |
dc.subject.keywordPlus | VIRUS-LIKE PARTICLES | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | INFLUENZA | - |
dc.subject.keywordPlus | DECISIONS | - |
dc.subject.keywordPlus | DIVISION | - |
dc.subject.keywordPlus | EPITOPE | - |
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