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DC Field | Value | Language |
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dc.citation.conferencePlace | KO | - |
dc.citation.conferencePlace | 판교(차바이오컴플렉스) | - |
dc.citation.number | 3 | - |
dc.citation.title | 2017년 한국생체재료학회 추계학술대회 | - |
dc.citation.volume | 21 | - |
dc.contributor.author | Lee, Kangseok | - |
dc.contributor.author | Hong, Jiu | - |
dc.contributor.author | Kim, Kyungchul | - |
dc.contributor.author | Kim, Soo Hyun | - |
dc.contributor.author | Lee, Hyunjung | - |
dc.contributor.author | Lee, Sung Kuk | - |
dc.contributor.author | Cha, Chaenyung | - |
dc.date.accessioned | 2023-12-19T18:08:15Z | - |
dc.date.available | 2023-12-19T18:08:15Z | - |
dc.date.created | 2017-10-24 | - |
dc.date.issued | 2017-10-20 | - |
dc.description.abstract | Spherical hydrogels (‘micro beads’) made from alginate has been explored and used for biomedical application, delivery of biomolecule and cell transplantation, although restricted mechanical strength and short-term structural cohesion. In this study, controlling mechanical properties and maintaining the long-term structural integrity of spherical hydrogels could be achieved by creating interpenetrating networks (IPN) of alginate and aqueous-soluble cellulose with divalent and trivalent ions. By using various the aqueous-soluble cellulose, with varying concentration of cellulose or types of ions, the moduli of the resulting hydrogels could be controlled in a wide range with a simple yet highly efficient method of engineering alginate beads. The aqueous-soluble cellulose is found to undergo crosslinking reaction with trivalent ions more favorably than divalent ions, processing a dual sequential ionic crosslinking scheme to create IPN of alginate and cellulose with divalent and trivalent ions, respectively. Especially, the aqueous-soluble anionic cellulose, containing either carboxylate or sulfonate, is easier to control mechanical properties than other types of celluloses. Furthermore, the IPN alginate-cellulose beads demonstrate enhanced resistance to harsh chemical environment as compared to alginate beads and suitability for biomedical applications by encapsulating microbial species and therapeutic agents for controlled release. |
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dc.identifier.bibliographicCitation | 2017년 한국생체재료학회 추계학술대회, v.21, no.3 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/39330 | - |
dc.language | 영어 | - |
dc.publisher | 한국생체재료학회 | - |
dc.title | Dual ionic crosslinked interpenetrating network of alginate-cellulose beads with enhanced mechanical properties for biocompatible encapsulation |
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dc.type | Conference Paper | - |
dc.date.conferenceDate | 2017-10-19 | - |
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