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dc.citation.endPage 694 -
dc.citation.number 12 -
dc.citation.startPage 685 -
dc.citation.title TRENDS IN NEUROSCIENCES -
dc.citation.volume 36 -
dc.contributor.author Chang, Karen T. -
dc.contributor.author Ro, Hyunah -
dc.contributor.author Wang, Wei -
dc.contributor.author Min, Kyung-Tai -
dc.date.accessioned 2023-12-22T03:12:03Z -
dc.date.available 2023-12-22T03:12:03Z -
dc.date.created 2013-09-30 -
dc.date.issued 2013-12 -
dc.description.abstract Intellectual disability is characterized by significantly impaired cognitive abilities and is due to various etiological factors, including both genetic and non-genetic causes. Two of the most common genetic forms of intellectual disability are Fragile X syndrome (FXS) and Down syndrome (DS). Recent studies have shown that proteins altered in FXS and DS can physically interact and participate in common signaling pathways regulating dendritic spine development and local protein synthesis, thus supporting the notion that spine dysmorphogenesis and abnormal local protein synthesis may be molecular underpinnings of intellectual disability. Here we review the molecular constituents regulating local protein synthesis and spine morphology and their alterations in FXS and DS. We argue that these changes might ultimately affect synaptic homeostasis and alter cognitive performance. -
dc.identifier.bibliographicCitation TRENDS IN NEUROSCIENCES, v.36, no.12, pp.685 - 694 -
dc.identifier.doi 10.1016/j.tins.2013.08.007 -
dc.identifier.issn 0166-2236 -
dc.identifier.scopusid 2-s2.0-84888876863 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/3883 -
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84888876863 -
dc.identifier.wosid 000329077500001 -
dc.language 영어 -
dc.publisher ELSEVIER SCIENCE LONDON -
dc.title Meeting at the crossroads: common mechanisms in Fragile X and Down syndrome -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Neurosciences -
dc.relation.journalResearchArea Neurosciences & Neurology -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -

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