dc.citation.conferencePlace |
KO |
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dc.citation.title |
119th Annual meeting of Korean Chemical Society |
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dc.contributor.author |
Palanikumar, L |
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dc.contributor.author |
유자형 |
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dc.date.accessioned |
2023-12-19T19:09:25Z |
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dc.date.available |
2023-12-19T19:09:25Z |
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dc.date.created |
2018-01-05 |
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dc.date.issued |
2017-04-19 |
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dc.description.abstract |
Targeted delivery mediated by ligand modified nanocarriers have been extensively pursued for cancer chemotherapy, however the efficiency is still limited by premature drug release after the administration. Herein, we represented a simple, one-pot synthesis and robust method by installing non-covalent polymer gatekeepers in mesoporous silica nanoparticles. The unmodified mesoporous silica nanocontainers have a high loading capacity for hydrophobic drugs. This is a tumor adaptable drug carrier made of disulfide bonded polyethylene glycol-pyridyl disulfide (PEG-PDS) polymer gatekeepers and can release drug upon the increased intracellular glutathione concentration. In-situ covalently crosslinked the PEG-PDS capped mesoporous silica nanoparticles have shown improved encapsulation to avoid the premature drug release. Intravenously injected non-covalent polymergatekeepers have led to hydrophobic doxorubicin in cancer cells and suppresses the tumor growth in mice. As compared to the self-assembled micelles, doxorubicin loaded polymergatekeeper mesoporous nanoparticles have shown improved tumor reducing capability. |
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dc.identifier.bibliographicCitation |
119th Annual meeting of Korean Chemical Society |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/38333 |
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dc.language |
영어 |
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dc.publisher |
Korean Chemical Society |
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dc.title |
Enhanced precision of in-vivo stable non-covalent polymergatekeepers in mesoporous silica nanoparticles for hydrophobic drug delivery in tumor therapy |
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dc.type |
Conference Paper |
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dc.date.conferenceDate |
2017-04-19 |
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