Wavefront engineering for in-vivo deep brain imaging

Abstract

The brain is a unique organ which still holds many challenges that must be overcome for deeper understanding. The relation between the structure and function of the brain is still a big mystery due to the diversity in cell type and functional connections. In this respect, optical imaging holds unique advantages with its molecular specificity and high spatiotemporal resolution which allows simultaneous observation of both structure and function of the brain. However, deep brain imaging requires the light to be delivered efficiently through multiple scattering caused by the thick tissue. In this talk, I will describe our recent developments in wavefront engineering that overcome this barrier and enable high resolution large volume deep brain imaging and through-skull imaging of live mice.